Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

Disruption of proteostasis, or protein homeostasis, is often associated with aberrant accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to cells by removing toxic protein aggregates and injured organelles in response to proteotoxic stress. However, the exact mecha...

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Detalles Bibliográficos
Autores principales: Lim, Junghyun, Lachenmayer, M. Lenard, Wu, Shuai, Liu, Wenchao, Kundu, Mondira, Wang, Rong, Komatsu, Masaaki, Oh, Young J., Zhao, Yanxiang, Yue, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344198/
https://www.ncbi.nlm.nih.gov/pubmed/25723488
http://dx.doi.org/10.1371/journal.pgen.1004987

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344198/
https://www.ncbi.nlm.nih.gov/pubmed/25723488
http://dx.doi.org/10.1371/journal.pgen.1004987

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