Pathway-Based Analysis of Genome-Wide siRNA Screens Reveals the Regulatory Landscape of App Processing

The progressive aggregation of Amyloid-β (Aβ) in the brain is a major trait of Alzheimer's Disease (AD). Aβ is produced as a result of proteolytic processing of the β-amyloid precursor protein (APP). Processing of APP is mediated by multiple enzymes, resulting in the production of distinct pept...

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Detalles Bibliográficos
Autores principales: Camargo, Luiz Miguel, Zhang, Xiaohua Douglas, Loerch, Patrick, Caceres, Ramon Miguel, Marine, Shane D., Uva, Paolo, Ferrer, Marc, de Rinaldis, Emanuele, Stone, David J., Majercak, John, Ray, William J., Yi-An, Chen, Shearman, Mark S., Mizuguchi, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344212/
https://www.ncbi.nlm.nih.gov/pubmed/25723573
http://dx.doi.org/10.1371/journal.pone.0115369

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