Cargando…

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation

Inducible nitric oxide synthase (iNOS) is a key enzyme in the macrophage inflammatory response, which is the source of nitric oxide (NO) that is potently induced in response to proinflammatory stimuli. However, the specific role of NO production, as distinct from iNOS induction, in macrophage inflam...

Descripción completa

Detalles Bibliográficos
Autores principales:	McNeill, Eileen, Crabtree, Mark J., Sahgal, Natasha, Patel, Jyoti, Chuaiphichai, Surawee, Iqbal, Asif J., Hale, Ashley B., Greaves, David R., Channon, Keith M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Science 2015
Materias:	Original Contribution
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344222/ https://www.ncbi.nlm.nih.gov/pubmed/25451639 http://dx.doi.org/10.1016/j.freeradbiomed.2014.10.575

Ejemplares similares

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
por: Douglas, Gillian, et al.
Publicado: (2018)

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
por: Chuaiphichai, Surawee, et al.
Publicado: (2017)

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
por: McNeill, Eileen, et al.
Publicado: (2018)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension()
por: Chuaiphichai, Surawee, et al.
Publicado: (2016)

A requirement for Gch1 and tetrahydrobiopterin in embryonic development
por: Douglas, Gillian, et al.
Publicado: (2015)

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm
por: Chuaiphichai, Surawee, et al.
Publicado: (2018)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology
por: Bailey, Jade D., et al.
Publicado: (2020)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
por: Crabtree, Mark J., et al.
Publicado: (2011)

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
por: Chuaiphichai, Surawee, et al.
Publicado: (2021)

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
por: Chuaiphichai, Surawee, et al.
Publicado: (2023)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
por: Bailey, Jade, et al.
Publicado: (2017)

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control
por: Patel, Jyoti, et al.
Publicado: (2018)

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation
por: Bailey, Jade D., et al.
Publicado: (2019)

Hydrodynamic Gene Delivery of CC Chemokine Binding Fc Fusion Proteins to Target Acute Vascular Inflammation In Vivo
por: McNeill, Eileen, et al.
Publicado: (2015)

m(6)A‐mediated regulation of PBX1‐GCH1 axis promotes gastric cancer proliferation and metastasis by elevating tetrahydrobiopterin levels
por: Liu, Yinan, et al.
Publicado: (2022)

Obesity-Induced Coronary Microvascular Disease Is Prevented by iNOS Deletion and Reversed by iNOS Inhibition
por: Shah, Soham A., et al.
Publicado: (2023)

The dual role of iNOS in cancer()
por: Vannini, Federica, et al.
Publicado: (2015)

Contrasting in vitro vs. in vivo effects of a cell membrane-specific CC-chemokine binding protein on macrophage chemotaxis
por: McNeill, Eileen, et al.
Publicado: (2014)

Tracking Monocyte Recruitment and Macrophage Accumulation in Atherosclerotic Plaque Progression Using a Novel hCD68GFP/ApoE(−/−) Reporter Mouse—Brief Report
por: McNeill, Eileen, et al.
Publicado: (2017)

Nox4 regulates Nrf2 and glutathione redox in cardiomyocytes in vivo
por: Brewer, Alison C., et al.
Publicado: (2011)

Mast cell tetrahydrobiopterin contributes to itch in mice
por: Zschiebsch, Katja, et al.
Publicado: (2018)

Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
por: Schweighöfer, Hanna, et al.
Publicado: (2014)

The Downstream Regulation of Chemokine Receptor Signalling: Implications for Atherosclerosis
por: Patel, Jyoti, et al.
Publicado: (2013)

The expressions of AMACR and iNOS in prostate adenocarcinomas
por: Ozgur, Tumay, et al.
Publicado: (2013)

Targeting iNOS to increase efficacy of immunotherapies
por: Ekmekcioglu, Suhendan, et al.
Publicado: (2017)

Recoupling the Cardiac Nitric Oxide Synthases: Tetrahydrobiopterin Synthesis and Recycling
por: Alkaitis, Matthew S., et al.
Publicado: (2012)

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling
por: Patel, Jyoti, et al.
Publicado: (2015)

Increased NOS coupling by the metabolite tetrahydrobiopterin (BH4) reduces preeclampsia/IUGR consequences
por: Chatre, Laurent, et al.
Publicado: (2022)

Upregulation of iNOS and phosphorylated eNOS in the implantation‐induced blastocysts of mice
por: Seki, Misato, et al.
Publicado: (2023)

Fractalkine Promotes Human Monocyte Survival via a Reduction in Oxidative Stress
por: White, Gemma E., et al.
Publicado: (2014)

iNOS polymorphism modulates iNOS/NO expression via impaired antioxidant and ROS content in P. vivax and P. falciparum infection
por: Kumar, Amod, et al.
Publicado: (2017)

Ligustilide Prevents Radiation Enteritis by Targeting Gch1/BH(4)/eNOS to Improve Intestinal Ischemia
por: Yan, Tao, et al.
Publicado: (2021)

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
por: Bailey, Jade, et al.
Publicado: (2018)

7-Hydroxy Frullanolide Ameliorates Isoproterenol-Induced Myocardial Injury through Modification of iNOS and Nrf2 Genes
por: Ullah, Saif, et al.
Publicado: (2023)

Aging and Insulin Resistance: Just Say iNOS
por: Evans, Joseph L., et al.
Publicado: (2013)

Recipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
por: Minamoto, Kanji, et al.
Publicado: (2002)

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS
por: Morsy, Mohamed A., et al.
Publicado: (2014)

The return of the Scarlet Pimpernel: cobalamin in inflammation II — cobalamins can both selectively promote all three nitric oxide synthases (NOS), particularly iNOS and eNOS, and, as needed, selectively inhibit iNOS and nNOS
por: Wheatley, Carmen
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_f1sk7att639lnslujpsnldppo1