Mechanism for the Anti-Diabetic Effect of Leptin

Leptin reverses hyperglycemia in T1D though reductions in HPA-mediated lipolysis resulting in reduced hepatic gluconeogenesis through both substrate delivery and allosteric mechanisms.

Detalles Bibliográficos
Autores principales: Perry, Rachel J., Zhang, Xian-Man, Zhang, Dongyan, Kumashiro, Naoki, Camporez, Joao-Paulo G., Cline, Gary W., Rothman, Douglas L., Shulman, Gerald I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344321/
https://www.ncbi.nlm.nih.gov/pubmed/24929951
http://dx.doi.org/10.1038/nm.3579
Descripción
Sumario:Leptin reverses hyperglycemia in T1D though reductions in HPA-mediated lipolysis resulting in reduced hepatic gluconeogenesis through both substrate delivery and allosteric mechanisms.

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