Cargando…
Mechanism for the Anti-Diabetic Effect of Leptin
Leptin reverses hyperglycemia in T1D though reductions in HPA-mediated lipolysis resulting in reduced hepatic gluconeogenesis through both substrate delivery and allosteric mechanisms.
Autores principales: | Perry, Rachel J., Zhang, Xian-Man, Zhang, Dongyan, Kumashiro, Naoki, Camporez, Joao-Paulo G., Cline, Gary W., Rothman, Douglas L., Shulman, Gerald I. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344321/ https://www.ncbi.nlm.nih.gov/pubmed/24929951 http://dx.doi.org/10.1038/nm.3579 |
Ejemplares similares
-
Metformin Inhibits Gluconeogenesis by a Redox-Dependent Mechanism In Vivo
por: Madiraju, Anila K., et al.
Publicado: (2018) -
Sex‐ and strain‐specific effects of mitochondrial uncoupling on age‐related metabolic diseases in high‐fat diet‐fed mice
por: Goedeke, Leigh, et al.
Publicado: (2022) -
Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
por: Perry, Rachel J., et al.
Publicado: (2017) -
Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA)
por: Perry, Rachel J., et al.
Publicado: (2018) -
Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism
por: Perry, Rachel J., et al.
Publicado: (2016)