Coverage recommendations for methylation analysis by whole genome bisulfite sequencing

Whole genome bisulfite sequencing (WGBS) allows genome-wide DNA methylation profiling but the associated high sequencing costs continue to limit its widespread application. We utilized several high coverage reference data sets to experimentally determine minimal sequencing requirements. Here, we pre...

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Detalles Bibliográficos
Autores principales: Ziller, Michael J., Hansen, Kasper D., Meissner, Alexander, Aryee, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344394/
https://www.ncbi.nlm.nih.gov/pubmed/25362363
http://dx.doi.org/10.1038/nmeth.3152

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