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Fungal Ku prevents permanent cell cycle arrest by suppressing DNA damage signaling at telomeres

The Ku heterodimer serves in the initial step in repairing DNA double-strand breaks by the non-homologous end-joining pathway. Besides this key function, Ku also plays a role in other cellular processes including telomere maintenance. Inactivation of Ku can lead to DNA repair defects and telomere ab...

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Detalles Bibliográficos
Autores principales:	de Sena-Tomás, Carmen, Yu, Eun Young, Calzada, Arturo, Holloman, William K., Lue, Neal F., Pérez-Martín, José
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344518/ https://www.ncbi.nlm.nih.gov/pubmed/25653166 http://dx.doi.org/10.1093/nar/gkv082

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