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Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing

Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. This highly restricted distribution must be co-determined by the thymidine hydroxylases (JBP1 and JBP2) that catalyze...

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Detalles Bibliográficos
Autores principales:	Genest, Paul-Andre, Baugh, Loren, Taipale, Alex, Zhao, Wanqi, Jan, Sabrina, van Luenen, Henri G.A.M., Korlach, Jonas, Clark, Tyson, Luong, Khai, Boitano, Matthew, Turner, Steve, Myler, Peter J., Borst, Piet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344527/ https://www.ncbi.nlm.nih.gov/pubmed/25662217 http://dx.doi.org/10.1093/nar/gkv095

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