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The Interaction between Epigenetics, Nutrition and the Development of Cancer
Unlike the genome, the epigenome can be modified and hence some epigenetic risk markers have the potential to be reversed. Such modifications take place by means of drugs, diet or environmental exposures. It is widely accepted that epigenetic modifications take place during early embryonic and primo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344568/ https://www.ncbi.nlm.nih.gov/pubmed/25647662 http://dx.doi.org/10.3390/nu7020922 |
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author | Bishop, Karen S. Ferguson, Lynnette R. |
author_facet | Bishop, Karen S. Ferguson, Lynnette R. |
author_sort | Bishop, Karen S. |
collection | PubMed |
description | Unlike the genome, the epigenome can be modified and hence some epigenetic risk markers have the potential to be reversed. Such modifications take place by means of drugs, diet or environmental exposures. It is widely accepted that epigenetic modifications take place during early embryonic and primordial cell development, but it is also important that we gain an understanding of the potential for such changes later in life. These “later life” epigenetic modifications in response to dietary intervention are the focus of this paper. The epigenetic modifications investigated include DNA methylation, histone modifications and the influence of microRNAs. The epigenotype could be used not only to predict susceptibility to certain cancers but also to assess the effectiveness of dietary modifications to reduce such risk. The influence of diet or dietary components on epigenetic modifications and the impact on cancer initiation or progression has been assessed herein. |
format | Online Article Text |
id | pubmed-4344568 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43445682015-03-18 The Interaction between Epigenetics, Nutrition and the Development of Cancer Bishop, Karen S. Ferguson, Lynnette R. Nutrients Review Unlike the genome, the epigenome can be modified and hence some epigenetic risk markers have the potential to be reversed. Such modifications take place by means of drugs, diet or environmental exposures. It is widely accepted that epigenetic modifications take place during early embryonic and primordial cell development, but it is also important that we gain an understanding of the potential for such changes later in life. These “later life” epigenetic modifications in response to dietary intervention are the focus of this paper. The epigenetic modifications investigated include DNA methylation, histone modifications and the influence of microRNAs. The epigenotype could be used not only to predict susceptibility to certain cancers but also to assess the effectiveness of dietary modifications to reduce such risk. The influence of diet or dietary components on epigenetic modifications and the impact on cancer initiation or progression has been assessed herein. MDPI 2015-01-30 /pmc/articles/PMC4344568/ /pubmed/25647662 http://dx.doi.org/10.3390/nu7020922 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bishop, Karen S. Ferguson, Lynnette R. The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title | The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title_full | The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title_fullStr | The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title_full_unstemmed | The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title_short | The Interaction between Epigenetics, Nutrition and the Development of Cancer |
title_sort | interaction between epigenetics, nutrition and the development of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344568/ https://www.ncbi.nlm.nih.gov/pubmed/25647662 http://dx.doi.org/10.3390/nu7020922 |
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