Cargando…
Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3)...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344616/ https://www.ncbi.nlm.nih.gov/pubmed/25689565 http://dx.doi.org/10.3390/md13021026 |
_version_ | 1782359449681264640 |
---|---|
author | Liu, Ying-Hua Li, Xiang-Yong Chen, Chih-Yu Zhang, Hong-Man Kang, Jing X. |
author_facet | Liu, Ying-Hua Li, Xiang-Yong Chen, Chih-Yu Zhang, Hong-Man Kang, Jing X. |
author_sort | Liu, Ying-Hua |
collection | PubMed |
description | Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight and the expression of Toll-like receptor 4 (TLR4) pathway components. LPS administration induced a dramatic loss of body weight within two days. Treatment with n-3 PUFA not only stopped loss of body weight but also gradually reversed it back to baseline levels within one week. Accordingly, the animals treated with n-3 PUFA exhibited markedly lower levels of inflammatory cytokines or markers in plasma and tissues, as well as down-regulation of TLR4 pathway components compared to animals without n-3 PUFA treatment or those treated with omega-6 PUFA. Our data demonstrate that n-3 PUFA intervention can suppress LPS-induced inflammation and weight loss via, at least in part, down-regulation of pro-inflammatory targets of the TLR4 signaling pathway, and highlight the therapeutic potential of n-3 PUFA in the management of sepsis. |
format | Online Article Text |
id | pubmed-4344616 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43446162015-03-18 Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice Liu, Ying-Hua Li, Xiang-Yong Chen, Chih-Yu Zhang, Hong-Man Kang, Jing X. Mar Drugs Article Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight and the expression of Toll-like receptor 4 (TLR4) pathway components. LPS administration induced a dramatic loss of body weight within two days. Treatment with n-3 PUFA not only stopped loss of body weight but also gradually reversed it back to baseline levels within one week. Accordingly, the animals treated with n-3 PUFA exhibited markedly lower levels of inflammatory cytokines or markers in plasma and tissues, as well as down-regulation of TLR4 pathway components compared to animals without n-3 PUFA treatment or those treated with omega-6 PUFA. Our data demonstrate that n-3 PUFA intervention can suppress LPS-induced inflammation and weight loss via, at least in part, down-regulation of pro-inflammatory targets of the TLR4 signaling pathway, and highlight the therapeutic potential of n-3 PUFA in the management of sepsis. MDPI 2015-02-13 /pmc/articles/PMC4344616/ /pubmed/25689565 http://dx.doi.org/10.3390/md13021026 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Liu, Ying-Hua Li, Xiang-Yong Chen, Chih-Yu Zhang, Hong-Man Kang, Jing X. Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title | Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title_full | Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title_fullStr | Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title_full_unstemmed | Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title_short | Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice |
title_sort | omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344616/ https://www.ncbi.nlm.nih.gov/pubmed/25689565 http://dx.doi.org/10.3390/md13021026 |
work_keys_str_mv | AT liuyinghua omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice AT lixiangyong omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice AT chenchihyu omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice AT zhanghongman omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice AT kangjingx omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice |