Cargando…

Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice

Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3)...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Ying-Hua, Li, Xiang-Yong, Chen, Chih-Yu, Zhang, Hong-Man, Kang, Jing X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344616/
https://www.ncbi.nlm.nih.gov/pubmed/25689565
http://dx.doi.org/10.3390/md13021026
_version_ 1782359449681264640
author Liu, Ying-Hua
Li, Xiang-Yong
Chen, Chih-Yu
Zhang, Hong-Man
Kang, Jing X.
author_facet Liu, Ying-Hua
Li, Xiang-Yong
Chen, Chih-Yu
Zhang, Hong-Man
Kang, Jing X.
author_sort Liu, Ying-Hua
collection PubMed
description Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight and the expression of Toll-like receptor 4 (TLR4) pathway components. LPS administration induced a dramatic loss of body weight within two days. Treatment with n-3 PUFA not only stopped loss of body weight but also gradually reversed it back to baseline levels within one week. Accordingly, the animals treated with n-3 PUFA exhibited markedly lower levels of inflammatory cytokines or markers in plasma and tissues, as well as down-regulation of TLR4 pathway components compared to animals without n-3 PUFA treatment or those treated with omega-6 PUFA. Our data demonstrate that n-3 PUFA intervention can suppress LPS-induced inflammation and weight loss via, at least in part, down-regulation of pro-inflammatory targets of the TLR4 signaling pathway, and highlight the therapeutic potential of n-3 PUFA in the management of sepsis.
format Online
Article
Text
id pubmed-4344616
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43446162015-03-18 Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice Liu, Ying-Hua Li, Xiang-Yong Chen, Chih-Yu Zhang, Hong-Man Kang, Jing X. Mar Drugs Article Bacterial endotoxin lipopolysaccharide (LPS)-induced sepsis is a critical medical condition, characterized by a severe systemic inflammation and rapid loss of muscle mass. Preventive and therapeutic strategies for this complex disease are still lacking. Here, we evaluated the effect of omega-3 (n-3) polyunsaturated fatty acid (PUFA) intervention on LPS-challenged mice with respect to inflammation, body weight and the expression of Toll-like receptor 4 (TLR4) pathway components. LPS administration induced a dramatic loss of body weight within two days. Treatment with n-3 PUFA not only stopped loss of body weight but also gradually reversed it back to baseline levels within one week. Accordingly, the animals treated with n-3 PUFA exhibited markedly lower levels of inflammatory cytokines or markers in plasma and tissues, as well as down-regulation of TLR4 pathway components compared to animals without n-3 PUFA treatment or those treated with omega-6 PUFA. Our data demonstrate that n-3 PUFA intervention can suppress LPS-induced inflammation and weight loss via, at least in part, down-regulation of pro-inflammatory targets of the TLR4 signaling pathway, and highlight the therapeutic potential of n-3 PUFA in the management of sepsis. MDPI 2015-02-13 /pmc/articles/PMC4344616/ /pubmed/25689565 http://dx.doi.org/10.3390/md13021026 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Ying-Hua
Li, Xiang-Yong
Chen, Chih-Yu
Zhang, Hong-Man
Kang, Jing X.
Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title_full Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title_fullStr Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title_full_unstemmed Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title_short Omega-3 Fatty Acid Intervention Suppresses Lipopolysaccharide-Induced Inflammation and Weight Loss in Mice
title_sort omega-3 fatty acid intervention suppresses lipopolysaccharide-induced inflammation and weight loss in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344616/
https://www.ncbi.nlm.nih.gov/pubmed/25689565
http://dx.doi.org/10.3390/md13021026
work_keys_str_mv AT liuyinghua omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice
AT lixiangyong omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice
AT chenchihyu omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice
AT zhanghongman omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice
AT kangjingx omega3fattyacidinterventionsuppresseslipopolysaccharideinducedinflammationandweightlossinmice