Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)

Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantl...

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Autores principales: Su, Yin-Di, Su, Tzu-Rong, Wen, Zhi-Hong, Hwang, Tsong-Long, Fang, Lee-Shing, Chen, Jih-Jung, Wu, Yang-Chang, Sheu, Jyh-Horng, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344617/
https://www.ncbi.nlm.nih.gov/pubmed/25689566
http://dx.doi.org/10.3390/md13021037
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author Su, Yin-Di
Su, Tzu-Rong
Wen, Zhi-Hong
Hwang, Tsong-Long
Fang, Lee-Shing
Chen, Jih-Jung
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_facet Su, Yin-Di
Su, Tzu-Rong
Wen, Zhi-Hong
Hwang, Tsong-Long
Fang, Lee-Shing
Chen, Jih-Jung
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
author_sort Su, Yin-Di
collection PubMed
description Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells.
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spelling pubmed-43446172015-03-18 Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae) Su, Yin-Di Su, Tzu-Rong Wen, Zhi-Hong Hwang, Tsong-Long Fang, Lee-Shing Chen, Jih-Jung Wu, Yang-Chang Sheu, Jyh-Horng Sung, Ping-Jyun Mar Drugs Article Two new briarane-type diterpenoids, briarenolides K (1) and L (2), were isolated from an octocoral identified as Briareum sp. The structures of new briaranes 1 and 2 were elucidated by spectroscopic methods. In the in vitro anti-inflammatory effects test, briaranes 1 and 2 were found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. MDPI 2015-02-13 /pmc/articles/PMC4344617/ /pubmed/25689566 http://dx.doi.org/10.3390/md13021037 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Su, Yin-Di
Su, Tzu-Rong
Wen, Zhi-Hong
Hwang, Tsong-Long
Fang, Lee-Shing
Chen, Jih-Jung
Wu, Yang-Chang
Sheu, Jyh-Horng
Sung, Ping-Jyun
Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_full Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_fullStr Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_full_unstemmed Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_short Briarenolides K and L, New Anti-Inflammatory Briarane Diterpenoids from an Octocoral Briareum sp. (Briareidae)
title_sort briarenolides k and l, new anti-inflammatory briarane diterpenoids from an octocoral briareum sp. (briareidae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344617/
https://www.ncbi.nlm.nih.gov/pubmed/25689566
http://dx.doi.org/10.3390/md13021037
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