Cargando…

Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the inte...

Descripción completa

Detalles Bibliográficos
Autores principales: Garrosa, Manuel, Jiménez, Pilar, Tejero, Jesús, Cabrero, Patricia, Cordoba-Diaz, Damián, Quinto, Emiliano J., Gayoso, Manuel J., Girbés, Tomás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344629/
https://www.ncbi.nlm.nih.gov/pubmed/25648843
http://dx.doi.org/10.3390/toxins7020367
_version_ 1782359452664463360
author Garrosa, Manuel
Jiménez, Pilar
Tejero, Jesús
Cabrero, Patricia
Cordoba-Diaz, Damián
Quinto, Emiliano J.
Gayoso, Manuel J.
Girbés, Tomás
author_facet Garrosa, Manuel
Jiménez, Pilar
Tejero, Jesús
Cabrero, Patricia
Cordoba-Diaz, Damián
Quinto, Emiliano J.
Gayoso, Manuel J.
Girbés, Tomás
author_sort Garrosa, Manuel
collection PubMed
description All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level.
format Online
Article
Text
id pubmed-4344629
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-43446292015-03-18 Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice Garrosa, Manuel Jiménez, Pilar Tejero, Jesús Cabrero, Patricia Cordoba-Diaz, Damián Quinto, Emiliano J. Gayoso, Manuel J. Girbés, Tomás Toxins (Basel) Article All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level. MDPI 2015-02-02 /pmc/articles/PMC4344629/ /pubmed/25648843 http://dx.doi.org/10.3390/toxins7020367 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Garrosa, Manuel
Jiménez, Pilar
Tejero, Jesús
Cabrero, Patricia
Cordoba-Diaz, Damián
Quinto, Emiliano J.
Gayoso, Manuel J.
Girbés, Tomás
Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title_full Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title_fullStr Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title_full_unstemmed Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title_short Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
title_sort toxicity of the anti-ribosomal lectin ebulin f in lungs and intestines in elderly mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344629/
https://www.ncbi.nlm.nih.gov/pubmed/25648843
http://dx.doi.org/10.3390/toxins7020367
work_keys_str_mv AT garrosamanuel toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT jimenezpilar toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT tejerojesus toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT cabreropatricia toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT cordobadiazdamian toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT quintoemilianoj toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT gayosomanuelj toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice
AT girbestomas toxicityoftheantiribosomallectinebulinfinlungsandintestinesinelderlymice