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Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice
All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the inte...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344629/ https://www.ncbi.nlm.nih.gov/pubmed/25648843 http://dx.doi.org/10.3390/toxins7020367 |
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author | Garrosa, Manuel Jiménez, Pilar Tejero, Jesús Cabrero, Patricia Cordoba-Diaz, Damián Quinto, Emiliano J. Gayoso, Manuel J. Girbés, Tomás |
author_facet | Garrosa, Manuel Jiménez, Pilar Tejero, Jesús Cabrero, Patricia Cordoba-Diaz, Damián Quinto, Emiliano J. Gayoso, Manuel J. Girbés, Tomás |
author_sort | Garrosa, Manuel |
collection | PubMed |
description | All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level. |
format | Online Article Text |
id | pubmed-4344629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43446292015-03-18 Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice Garrosa, Manuel Jiménez, Pilar Tejero, Jesús Cabrero, Patricia Cordoba-Diaz, Damián Quinto, Emiliano J. Gayoso, Manuel J. Girbés, Tomás Toxins (Basel) Article All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level. MDPI 2015-02-02 /pmc/articles/PMC4344629/ /pubmed/25648843 http://dx.doi.org/10.3390/toxins7020367 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Garrosa, Manuel Jiménez, Pilar Tejero, Jesús Cabrero, Patricia Cordoba-Diaz, Damián Quinto, Emiliano J. Gayoso, Manuel J. Girbés, Tomás Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title | Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title_full | Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title_fullStr | Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title_full_unstemmed | Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title_short | Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice |
title_sort | toxicity of the anti-ribosomal lectin ebulin f in lungs and intestines in elderly mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344629/ https://www.ncbi.nlm.nih.gov/pubmed/25648843 http://dx.doi.org/10.3390/toxins7020367 |
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