Cargando…
Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344726/ https://www.ncbi.nlm.nih.gov/pubmed/25690002 http://dx.doi.org/10.3390/ijerph120202289 |
_version_ | 1782359474788368384 |
---|---|
author | Numan, Mohamed Saber Brown, Jacques P. Michou, Laëtitia |
author_facet | Numan, Mohamed Saber Brown, Jacques P. Michou, Laëtitia |
author_sort | Numan, Mohamed Saber |
collection | PubMed |
description | Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur. |
format | Online Article Text |
id | pubmed-4344726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43447262015-03-18 Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases Numan, Mohamed Saber Brown, Jacques P. Michou, Laëtitia Int J Environ Res Public Health Review Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur. MDPI 2015-02-17 2015-02 /pmc/articles/PMC4344726/ /pubmed/25690002 http://dx.doi.org/10.3390/ijerph120202289 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Numan, Mohamed Saber Brown, Jacques P. Michou, Laëtitia Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title | Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title_full | Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title_fullStr | Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title_full_unstemmed | Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title_short | Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases |
title_sort | impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344726/ https://www.ncbi.nlm.nih.gov/pubmed/25690002 http://dx.doi.org/10.3390/ijerph120202289 |
work_keys_str_mv | AT numanmohamedsaber impactofairpollutantsonoxidativestressincommonautophagymediatedagingdiseases AT brownjacquesp impactofairpollutantsonoxidativestressincommonautophagymediatedagingdiseases AT michoulaetitia impactofairpollutantsonoxidativestressincommonautophagymediatedagingdiseases |