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Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases

Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of...

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Detalles Bibliográficos
Autores principales: Numan, Mohamed Saber, Brown, Jacques P., Michou, Laëtitia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344726/
https://www.ncbi.nlm.nih.gov/pubmed/25690002
http://dx.doi.org/10.3390/ijerph120202289
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author Numan, Mohamed Saber
Brown, Jacques P.
Michou, Laëtitia
author_facet Numan, Mohamed Saber
Brown, Jacques P.
Michou, Laëtitia
author_sort Numan, Mohamed Saber
collection PubMed
description Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur.
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spelling pubmed-43447262015-03-18 Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases Numan, Mohamed Saber Brown, Jacques P. Michou, Laëtitia Int J Environ Res Public Health Review Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur. MDPI 2015-02-17 2015-02 /pmc/articles/PMC4344726/ /pubmed/25690002 http://dx.doi.org/10.3390/ijerph120202289 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Numan, Mohamed Saber
Brown, Jacques P.
Michou, Laëtitia
Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title_full Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title_fullStr Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title_full_unstemmed Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title_short Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases
title_sort impact of air pollutants on oxidative stress in common autophagy-mediated aging diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344726/
https://www.ncbi.nlm.nih.gov/pubmed/25690002
http://dx.doi.org/10.3390/ijerph120202289
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