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A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer

Targeted cancer therapies, while often effective, have limited utility due to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their...

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Detalles Bibliográficos
Autores principales: Kasinski, Andrea L., Kelnar, Kevin, Stahlhut, Carlos, Orellana, Esteban, Zhao, Jane, Shimer, Eliot, Dysart, Sarah, Chen, Xiaowei, Bader, Andreas G., Slack, Frank J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345154/
https://www.ncbi.nlm.nih.gov/pubmed/25174400
http://dx.doi.org/10.1038/onc.2014.282
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author Kasinski, Andrea L.
Kelnar, Kevin
Stahlhut, Carlos
Orellana, Esteban
Zhao, Jane
Shimer, Eliot
Dysart, Sarah
Chen, Xiaowei
Bader, Andreas G.
Slack, Frank J.
author_facet Kasinski, Andrea L.
Kelnar, Kevin
Stahlhut, Carlos
Orellana, Esteban
Zhao, Jane
Shimer, Eliot
Dysart, Sarah
Chen, Xiaowei
Bader, Andreas G.
Slack, Frank J.
author_sort Kasinski, Andrea L.
collection PubMed
description Targeted cancer therapies, while often effective, have limited utility due to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to repress multiple oncogenic pathways at once. Here we treated the aggressive Kras;p53 non-small cell lung cancer mouse model and demonstrated efficacy with a combination of two tumor-suppressive microRNAs. Systemic nano-delivery of miR-34 and let-7 suppressed tumor growth leading to a survival advantage. This combinatorial microRNA therapeutic approach engages numerous components of tumor-cell addictive pathways and highlights the ability to deliver multiple microRNAs in a safe and effective manner to target lung tissue.
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spelling pubmed-43451542016-01-01 A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer Kasinski, Andrea L. Kelnar, Kevin Stahlhut, Carlos Orellana, Esteban Zhao, Jane Shimer, Eliot Dysart, Sarah Chen, Xiaowei Bader, Andreas G. Slack, Frank J. Oncogene Article Targeted cancer therapies, while often effective, have limited utility due to preexisting primary or acquired secondary resistance. Consequently, agents are sometimes used in combination to simultaneously affect multiple targets. MicroRNA mimics are excellent therapeutic candidates because of their ability to repress multiple oncogenic pathways at once. Here we treated the aggressive Kras;p53 non-small cell lung cancer mouse model and demonstrated efficacy with a combination of two tumor-suppressive microRNAs. Systemic nano-delivery of miR-34 and let-7 suppressed tumor growth leading to a survival advantage. This combinatorial microRNA therapeutic approach engages numerous components of tumor-cell addictive pathways and highlights the ability to deliver multiple microRNAs in a safe and effective manner to target lung tissue. 2014-09-01 2015-07 /pmc/articles/PMC4345154/ /pubmed/25174400 http://dx.doi.org/10.1038/onc.2014.282 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Kasinski, Andrea L.
Kelnar, Kevin
Stahlhut, Carlos
Orellana, Esteban
Zhao, Jane
Shimer, Eliot
Dysart, Sarah
Chen, Xiaowei
Bader, Andreas G.
Slack, Frank J.
A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title_full A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title_fullStr A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title_full_unstemmed A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title_short A combinatorial microRNA therapeutics approach to suppressing non-small cell lung cancer
title_sort combinatorial microrna therapeutics approach to suppressing non-small cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345154/
https://www.ncbi.nlm.nih.gov/pubmed/25174400
http://dx.doi.org/10.1038/onc.2014.282
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