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Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry

Lysine-specific demethylase 1 (LSD1/KDM1A), a histone-modifying enzyme, is upregulated in many cancers, especially in neuroblastoma, breast cancer and hepatoma. We have established a simple method to measure LSD1 activity using a synthetic N-terminal 21-mer peptide of histone H3, which is dimethylat...

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Detalles Bibliográficos
Autores principales:	Sakane, Chiharu, Ohta, Hiromichi, Shidoji, Yoshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	the Society for Free Radical Research Japan 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345185/ https://www.ncbi.nlm.nih.gov/pubmed/25759518 http://dx.doi.org/10.3164/jcbn.14-99

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