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Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study
OBJECTIVE: The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. METHODS: Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKR...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Neurosurgical Society
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345197/ https://www.ncbi.nlm.nih.gov/pubmed/25733986 http://dx.doi.org/10.3340/jkns.2015.57.2.77 |
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author | Park, Seong-Hyun Hwang, Jeong-Hyun Hwang, Sung-Kyoo |
author_facet | Park, Seong-Hyun Hwang, Jeong-Hyun Hwang, Sung-Kyoo |
author_sort | Park, Seong-Hyun |
collection | PubMed |
description | OBJECTIVE: The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. METHODS: Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. RESULTS: The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. CONCLUSION: Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma. |
format | Online Article Text |
id | pubmed-4345197 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Neurosurgical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43451972015-03-02 Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study Park, Seong-Hyun Hwang, Jeong-Hyun Hwang, Sung-Kyoo J Korean Neurosurg Soc Laboratory Investigation OBJECTIVE: The purpose of this study was to investigate changes in the plasma level of vascular endothelial growth factor (VEGF) after Gamma Knife radiosurgery (GKRS) for the treatment of meningioma. METHODS: Fourteen patients with meningiomas had peripheral venous blood collected at the time of GKRS and at 1 week, 1 month, 3 month and 6 month visits. Plasma VEGF levels were measured using commercially available enzyme-linked immunosorbent assay. For controls, peripheral blood samples were obtained from 20 healthy volunteers. RESULTS: The mean plasma VEGF level (29.6 pg/mL) in patients with meningiomas before GKRS was significantly lower than that of the control group (62.4 pg/mL, p=0.019). At 1 week after GKRS, the mean plasma VEGF levels decreased to 23.4 pg/mL, and dropped to 13.9 pg/mL at 1 month, 14.8 pg/mL at 3 months, then increased to 27.7 pg/mL at 6 months. Two patients (14.3%) with peritumoral edema (PTE) showed a level of VEGF 6 months after GKRS higher than their preradiosurgical level. There was no significant association found in an analysis of correlation between PTE and tumor size, marginal dose, age, and sex. CONCLUSION: Our study is first in demonstrating changes of plasma VEGF after stereotactic radiosurgery (SRS) for meningioma. This study may provide a stimulus for more work related to whether measurement of plasma level has a correlation with tumor response after SRS for meningioma. The Korean Neurosurgical Society 2015-02 2015-02-26 /pmc/articles/PMC4345197/ /pubmed/25733986 http://dx.doi.org/10.3340/jkns.2015.57.2.77 Text en Copyright © 2015 The Korean Neurosurgical Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Laboratory Investigation Park, Seong-Hyun Hwang, Jeong-Hyun Hwang, Sung-Kyoo Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title | Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title_full | Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title_fullStr | Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title_full_unstemmed | Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title_short | Change in Plasma Vascular Endothelial Growth Factor after Gamma Knife Radiosurgery for Meningioma: A Preliminary Study |
title_sort | change in plasma vascular endothelial growth factor after gamma knife radiosurgery for meningioma: a preliminary study |
topic | Laboratory Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345197/ https://www.ncbi.nlm.nih.gov/pubmed/25733986 http://dx.doi.org/10.3340/jkns.2015.57.2.77 |
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