Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease

Objective. To investigate the esophageal function tests in British and Chinese patients with gastroesophageal reflux disease (GERD). Methods. Patients with GERD were selected from the functional gut clinic, London, and digestive department, Beijing Chao-Yang Hospital, after taking the examinations o...

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Autores principales: Gao, Feng, Leach, Samantha, Hao, Jian Yu, Shang, Zhan Min, Hobson, Anthony Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345251/
https://www.ncbi.nlm.nih.gov/pubmed/25784929
http://dx.doi.org/10.1155/2015/127275
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author Gao, Feng
Leach, Samantha
Hao, Jian Yu
Shang, Zhan Min
Hobson, Anthony Robert
author_facet Gao, Feng
Leach, Samantha
Hao, Jian Yu
Shang, Zhan Min
Hobson, Anthony Robert
author_sort Gao, Feng
collection PubMed
description Objective. To investigate the esophageal function tests in British and Chinese patients with gastroesophageal reflux disease (GERD). Methods. Patients with GERD were selected from the functional gut clinic, London, and digestive department, Beijing Chao-Yang Hospital, after taking the examinations of High-resolution Manometry and Impedance (HRiM) and 24-hour Multi-Channel Intraluminal Impedance and pH Recording (MII/pH) between 2013 and 2014. Chinese healthy volunteers who undertook HRiM were also selected as control group. Results. Fifty-nine British and 82 Chinese patients with GERD and 62 Chinese healthy volunteers were entered. Values for British patients, Chinese patients, and healthy volunteers were as follows: Lower esophageal sphincter pressure (LESP) 16.0 ± 8.6, 16.5 ± 10.0, and 26.4 ± 10.9 mmHg, peristalsis (normal/small break/large break) 24/12/23, 44/10/28, and 57/1/4, total bolus transit time (TBTT) 7.3 ± 1.3, 7.6 ± 1.2, and 6.9 ± 0.9 s, and complete bolus transit rate (CBTR) 66.7 ± 37.8, 61.7 ± 36.4, and 90.3 ± 14.0%, respectively. Stepwise linear regression analysis showed that age, gender, and ethnicity did not have significant effect on LESP, TBTT, esophageal peristalsis, and CBTR in patients with GERD. Conclusions. British and Chinese patients with GERD presented similar values of LESP, TBTT, and impaired esophageal peristalsis and CBTR.
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spelling pubmed-43452512015-03-17 Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease Gao, Feng Leach, Samantha Hao, Jian Yu Shang, Zhan Min Hobson, Anthony Robert Gastroenterol Res Pract Clinical Study Objective. To investigate the esophageal function tests in British and Chinese patients with gastroesophageal reflux disease (GERD). Methods. Patients with GERD were selected from the functional gut clinic, London, and digestive department, Beijing Chao-Yang Hospital, after taking the examinations of High-resolution Manometry and Impedance (HRiM) and 24-hour Multi-Channel Intraluminal Impedance and pH Recording (MII/pH) between 2013 and 2014. Chinese healthy volunteers who undertook HRiM were also selected as control group. Results. Fifty-nine British and 82 Chinese patients with GERD and 62 Chinese healthy volunteers were entered. Values for British patients, Chinese patients, and healthy volunteers were as follows: Lower esophageal sphincter pressure (LESP) 16.0 ± 8.6, 16.5 ± 10.0, and 26.4 ± 10.9 mmHg, peristalsis (normal/small break/large break) 24/12/23, 44/10/28, and 57/1/4, total bolus transit time (TBTT) 7.3 ± 1.3, 7.6 ± 1.2, and 6.9 ± 0.9 s, and complete bolus transit rate (CBTR) 66.7 ± 37.8, 61.7 ± 36.4, and 90.3 ± 14.0%, respectively. Stepwise linear regression analysis showed that age, gender, and ethnicity did not have significant effect on LESP, TBTT, esophageal peristalsis, and CBTR in patients with GERD. Conclusions. British and Chinese patients with GERD presented similar values of LESP, TBTT, and impaired esophageal peristalsis and CBTR. Hindawi Publishing Corporation 2015 2015-02-16 /pmc/articles/PMC4345251/ /pubmed/25784929 http://dx.doi.org/10.1155/2015/127275 Text en Copyright © 2015 Feng Gao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Gao, Feng
Leach, Samantha
Hao, Jian Yu
Shang, Zhan Min
Hobson, Anthony Robert
Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title_full Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title_fullStr Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title_full_unstemmed Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title_short Comparisons of Esophageal Function Tests between Chinese and British Patients with Gastroesophageal Reflux Disease
title_sort comparisons of esophageal function tests between chinese and british patients with gastroesophageal reflux disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345251/
https://www.ncbi.nlm.nih.gov/pubmed/25784929
http://dx.doi.org/10.1155/2015/127275
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