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Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran

INTRODUCTION: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of I...

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Autores principales: Hashemi, Mohammad, Ebrahimi, Mahboubeh, Amininia, Shadi, Naderi, Majid, Eskandari-Nasab, Ebrahim, Taheri, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345296/
https://www.ncbi.nlm.nih.gov/pubmed/25774266
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author Hashemi, Mohammad
Ebrahimi, Mahboubeh
Amininia, Shadi
Naderi, Majid
Eskandari-Nasab, Ebrahim
Taheri, Mohsen
author_facet Hashemi, Mohammad
Ebrahimi, Mahboubeh
Amininia, Shadi
Naderi, Majid
Eskandari-Nasab, Ebrahim
Taheri, Mohsen
author_sort Hashemi, Mohammad
collection PubMed
description INTRODUCTION: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population. METHODS: This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR). RESULTS: Our findings showed that neither rs3102735 nor rs2073617 variants were associated with ALL in a sample of Iranian population. Concerning rs3102735 polymorphism, the age of ALL predispositions was significantly higher in TC+CC genotype than TT genotype (P=0.032). Furthermore, the CSF involvement was significantly higher in ALL subjects carrying TC+CC genotype (p=0.044). CONCLUSION: We found no association between OPG (rs3102735, rs2073617) gene polymorphisms and risk of childhood ALL. Further studies with larger sample sizes and various ethnicities are necessary to verify our findings.
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spelling pubmed-43452962015-03-13 Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran Hashemi, Mohammad Ebrahimi, Mahboubeh Amininia, Shadi Naderi, Majid Eskandari-Nasab, Ebrahim Taheri, Mohsen Int J Hematol Oncol Stem Cell Res Original Article INTRODUCTION: Osteoprotegerin (OPG), a soluble decoy receptor secreted by osteoblasts, binds RANK-L, preventing stimulation of osteoclastogenesis. In the present study we aimed to investigate the impact of OPG variants and susceptibility to childhood acute lymphocytic leukemia (ALL) in a sample of Iranian population. METHODS: This case-control study was done on 98 ALL and 124 healthy children. We genotyped the polymorphisms using tetra-primer ARMS-PCR (T-ARMS-PCR). RESULTS: Our findings showed that neither rs3102735 nor rs2073617 variants were associated with ALL in a sample of Iranian population. Concerning rs3102735 polymorphism, the age of ALL predispositions was significantly higher in TC+CC genotype than TT genotype (P=0.032). Furthermore, the CSF involvement was significantly higher in ALL subjects carrying TC+CC genotype (p=0.044). CONCLUSION: We found no association between OPG (rs3102735, rs2073617) gene polymorphisms and risk of childhood ALL. Further studies with larger sample sizes and various ethnicities are necessary to verify our findings. Tehran University of Medical Sciences 2014-10-01 /pmc/articles/PMC4345296/ /pubmed/25774266 Text en Copyright: © International Journal of Hematology-Oncology and Stem Cell Research & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Original Article
Hashemi, Mohammad
Ebrahimi, Mahboubeh
Amininia, Shadi
Naderi, Majid
Eskandari-Nasab, Ebrahim
Taheri, Mohsen
Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title_full Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title_fullStr Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title_full_unstemmed Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title_short Evaluation of rs3102735 and rs2073617 Osteoprotegerin Gene Polymorphisms and the Risk of Childhood Acute lymphoblastic Leukemia in Zahedan Southeast Iran
title_sort evaluation of rs3102735 and rs2073617 osteoprotegerin gene polymorphisms and the risk of childhood acute lymphoblastic leukemia in zahedan southeast iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345296/
https://www.ncbi.nlm.nih.gov/pubmed/25774266
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