Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA

Using pre-miR-451 as a model molecule, we have characterized the general molecular properties of small hairpin RNAs that are processed into potent small interfering RNAs (siRNA) by Argonaute2 (Ago2). The Ago2-sliced siRNAs (sli-siRNAs) have the same silencing potency as the classical Dicer diced siR...

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Detalles Bibliográficos
Autores principales: Sun, Guihua, Yeh, Spencer Yele, Yuan, Christine Wan-Yin, Chiu, Margaret Jean-Yih, Yung, Bryan Shing Hei, Yen, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345305/
https://www.ncbi.nlm.nih.gov/pubmed/25602583
http://dx.doi.org/10.1038/mtna.2014.73

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345305/
https://www.ncbi.nlm.nih.gov/pubmed/25602583
http://dx.doi.org/10.1038/mtna.2014.73

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