High-affinity RNA Aptamers Against the HIV-1 Protease Inhibit Both In Vitro Protease Activity and Late Events of Viral Replication

HIV-1 aspartyl protease (PR) plays a key role in virion morphogenesis, underscoring the effectiveness of protease inhibitors (PI). Despite their utility, side effects and drug-resistance remains a problem. We report the development of RNA aptamers as inhibitors of HIV-1 PR for potential use in anti-...

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Detalles Bibliográficos
Autores principales: Duclair, Sonald, Gautam, Archana, Ellington, Andrew, Prasad, Vinayaka R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345311/
https://www.ncbi.nlm.nih.gov/pubmed/25689224
http://dx.doi.org/10.1038/mtna.2015.1

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