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Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates

Spontaneous eyeblink rates greatly vary among individuals from several blinks to a few dozen blinks per minute. Because dopamine agonists immediately increase the blink rate, individual differences in blink rate are used as a behavioral index of central dopamine functioning. However, an association...

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Autores principales: Nakano, Tamami, Kuriyama, Chiho, Himichi, Toshiyuki, Nomura, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345315/
https://www.ncbi.nlm.nih.gov/pubmed/25729002
http://dx.doi.org/10.1038/srep08658
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author Nakano, Tamami
Kuriyama, Chiho
Himichi, Toshiyuki
Nomura, Michio
author_facet Nakano, Tamami
Kuriyama, Chiho
Himichi, Toshiyuki
Nomura, Michio
author_sort Nakano, Tamami
collection PubMed
description Spontaneous eyeblink rates greatly vary among individuals from several blinks to a few dozen blinks per minute. Because dopamine agonists immediately increase the blink rate, individual differences in blink rate are used as a behavioral index of central dopamine functioning. However, an association of the blink rate with polymorphisms in dopamine-related genes has yet not been found. In this study, we demonstrated that a genetic variation of the nicotinic acetylcholine receptor CHRNA4 (rs1044396) increased the blink rate while watching a video. A receiver operating characteristic analysis revealed that the blink rate predicts a genetic variation in the nicotinic receptor gene with a significant discrimination level (0.66, p < 0.004). The present study suggests that differences in sensitivity to acetylcholine because of the genetic variation of the nicotinic receptor are associated with individual differences in spontaneous eye blink rate.
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spelling pubmed-43453152015-03-10 Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates Nakano, Tamami Kuriyama, Chiho Himichi, Toshiyuki Nomura, Michio Sci Rep Article Spontaneous eyeblink rates greatly vary among individuals from several blinks to a few dozen blinks per minute. Because dopamine agonists immediately increase the blink rate, individual differences in blink rate are used as a behavioral index of central dopamine functioning. However, an association of the blink rate with polymorphisms in dopamine-related genes has yet not been found. In this study, we demonstrated that a genetic variation of the nicotinic acetylcholine receptor CHRNA4 (rs1044396) increased the blink rate while watching a video. A receiver operating characteristic analysis revealed that the blink rate predicts a genetic variation in the nicotinic receptor gene with a significant discrimination level (0.66, p < 0.004). The present study suggests that differences in sensitivity to acetylcholine because of the genetic variation of the nicotinic receptor are associated with individual differences in spontaneous eye blink rate. Nature Publishing Group 2015-03-02 /pmc/articles/PMC4345315/ /pubmed/25729002 http://dx.doi.org/10.1038/srep08658 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Nakano, Tamami
Kuriyama, Chiho
Himichi, Toshiyuki
Nomura, Michio
Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title_full Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title_fullStr Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title_full_unstemmed Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title_short Association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
title_sort association of a nicotinic receptor gene polymorphism with spontaneous eyeblink rates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345315/
https://www.ncbi.nlm.nih.gov/pubmed/25729002
http://dx.doi.org/10.1038/srep08658
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