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Seahorse-derived peptide suppresses invasive migration of HT1080 fibrosarcoma cells by competing with intracellular α-enolase for plasminogen binding and inhibiting uPA-mediated activation of plasminogen

α-Enolase is a glycolytic enzyme and a surface receptor for plasminogen. α-Enolase-bound plasminogen promotes tumor cell invasion and cancer metastasis by activating plasmin and consequently degrading the extracellular matrix degradation. Therefore, α-enolase and plasminogen are novel targets for ca...

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Detalles Bibliográficos
Autores principales:	Kim, Yong-Tae, Kim, Se-kwon, Jeon, You-Jin, Park, Sun Joo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Biochemistry and Molecular Biology 2014
Materias:	Research-Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345514/ https://www.ncbi.nlm.nih.gov/pubmed/24602611 http://dx.doi.org/10.5483/BMBRep.2014.47.12.235

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