CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1

The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed...

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Detalles Bibliográficos
Autores principales: MATSUYAMA, MUTSUSHI, HANEDA, CHIEMI, KATO, KAZUO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2013
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345667/
https://www.ncbi.nlm.nih.gov/pubmed/24640181
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author MATSUYAMA, MUTSUSHI
HANEDA, CHIEMI
KATO, KAZUO
author_facet MATSUYAMA, MUTSUSHI
HANEDA, CHIEMI
KATO, KAZUO
author_sort MATSUYAMA, MUTSUSHI
collection PubMed
description The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations.
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spelling pubmed-43456672015-03-04 CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1 MATSUYAMA, MUTSUSHI HANEDA, CHIEMI KATO, KAZUO Nagoya J Med Sci Short Communication The ACI rats developed hereditary renal malformations including agenesis and hydronephrosis at moderate penetrance. During construction of a variety of congenic strains based on ACI/Mna (ACI), BUF/Mna (BUF), and WKY/NCrj (WKY) rats, we found that the renal malformations were significantly suppressed by introgression of a segment of chromosome 13 of BUF rats containing Pur1 locus. It is plausible that this region contain a modifier locus influencing development of renal malformations. Nagoya University 2013-08 /pmc/articles/PMC4345667/ /pubmed/24640181 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
MATSUYAMA, MUTSUSHI
HANEDA, CHIEMI
KATO, KAZUO
CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title_full CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title_fullStr CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title_full_unstemmed CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title_short CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1
title_sort congenic strain differences of renal malformations in aci/mna rats by introgression of the chromosomal region of buf/mna rats containing pur1
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345667/
https://www.ncbi.nlm.nih.gov/pubmed/24640181
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