Cargando…

DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY

Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PS...

Descripción completa

Detalles Bibliográficos
Autores principales: HIGASHIBATA, TAKAHIRO, NAITO, MARIKO, MORI, ATSUYOSHI, OZAWA, NORIYO, FURUTA, MASATOSHI, TSUCHIYA, RUMI, KOYAMA, ERINA, MORITA, EMI, KAWAI, SAYO, OKADA, RIEKO, YIN, GUANG, WAKAI, KENJI, HAMAJIMA, NOBUYUKI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345699/
https://www.ncbi.nlm.nih.gov/pubmed/23544270
_version_ 1782359610002243584
author HIGASHIBATA, TAKAHIRO
NAITO, MARIKO
MORI, ATSUYOSHI
OZAWA, NORIYO
FURUTA, MASATOSHI
TSUCHIYA, RUMI
KOYAMA, ERINA
MORITA, EMI
KAWAI, SAYO
OKADA, RIEKO
YIN, GUANG
WAKAI, KENJI
HAMAJIMA, NOBUYUKI
author_facet HIGASHIBATA, TAKAHIRO
NAITO, MARIKO
MORI, ATSUYOSHI
OZAWA, NORIYO
FURUTA, MASATOSHI
TSUCHIYA, RUMI
KOYAMA, ERINA
MORITA, EMI
KAWAI, SAYO
OKADA, RIEKO
YIN, GUANG
WAKAI, KENJI
HAMAJIMA, NOBUYUKI
author_sort HIGASHIBATA, TAKAHIRO
collection PubMed
description Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798-rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69.
format Online
Article
Text
id pubmed-4345699
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Nagoya University
record_format MEDLINE/PubMed
spelling pubmed-43456992015-03-04 DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY HIGASHIBATA, TAKAHIRO NAITO, MARIKO MORI, ATSUYOSHI OZAWA, NORIYO FURUTA, MASATOSHI TSUCHIYA, RUMI KOYAMA, ERINA MORITA, EMI KAWAI, SAYO OKADA, RIEKO YIN, GUANG WAKAI, KENJI HAMAJIMA, NOBUYUKI Nagoya J Med Sci Original Paper Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798-rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69. Nagoya University 2013-02 /pmc/articles/PMC4345699/ /pubmed/23544270 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Paper
HIGASHIBATA, TAKAHIRO
NAITO, MARIKO
MORI, ATSUYOSHI
OZAWA, NORIYO
FURUTA, MASATOSHI
TSUCHIYA, RUMI
KOYAMA, ERINA
MORITA, EMI
KAWAI, SAYO
OKADA, RIEKO
YIN, GUANG
WAKAI, KENJI
HAMAJIMA, NOBUYUKI
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title_full DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title_fullStr DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title_full_unstemmed DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title_short DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
title_sort dpp4 genetic variants influence baseline prostate-specific antigen levels: the j-micc study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345699/
https://www.ncbi.nlm.nih.gov/pubmed/23544270
work_keys_str_mv AT higashibatatakahiro dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT naitomariko dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT moriatsuyoshi dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT ozawanoriyo dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT furutamasatoshi dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT tsuchiyarumi dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT koyamaerina dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT moritaemi dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT kawaisayo dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT okadarieko dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT yinguang dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT wakaikenji dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy
AT hamajimanobuyuki dpp4geneticvariantsinfluencebaselineprostatespecificantigenlevelsthejmiccstudy