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DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY
Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PS...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345699/ https://www.ncbi.nlm.nih.gov/pubmed/23544270 |
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author | HIGASHIBATA, TAKAHIRO NAITO, MARIKO MORI, ATSUYOSHI OZAWA, NORIYO FURUTA, MASATOSHI TSUCHIYA, RUMI KOYAMA, ERINA MORITA, EMI KAWAI, SAYO OKADA, RIEKO YIN, GUANG WAKAI, KENJI HAMAJIMA, NOBUYUKI |
author_facet | HIGASHIBATA, TAKAHIRO NAITO, MARIKO MORI, ATSUYOSHI OZAWA, NORIYO FURUTA, MASATOSHI TSUCHIYA, RUMI KOYAMA, ERINA MORITA, EMI KAWAI, SAYO OKADA, RIEKO YIN, GUANG WAKAI, KENJI HAMAJIMA, NOBUYUKI |
author_sort | HIGASHIBATA, TAKAHIRO |
collection | PubMed |
description | Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798-rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69. |
format | Online Article Text |
id | pubmed-4345699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-43456992015-03-04 DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY HIGASHIBATA, TAKAHIRO NAITO, MARIKO MORI, ATSUYOSHI OZAWA, NORIYO FURUTA, MASATOSHI TSUCHIYA, RUMI KOYAMA, ERINA MORITA, EMI KAWAI, SAYO OKADA, RIEKO YIN, GUANG WAKAI, KENJI HAMAJIMA, NOBUYUKI Nagoya J Med Sci Original Paper Prostate specific antigen (PSA) testing plays a major role in prostate cancer screening; however, the low positive predictive value of PSA testing leads to many unnecessary biopsies. Genetic background is one of factors that could cause it. That’s why an association between genetic background and PSA levels should be elucidated. This study aimed to investigate whether DPP4 genetic variants are associated with baseline PSA levels. A cross-sectional study was performed on 2,074 Japanese men aged between 35 and 69 in the Shizuoka area from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Three DPP4 tagging single nucleotide polymorphisms (SNPs) were selected for genotyping: rs3788979 (A/G), rs7608798 (T/C), and rs2268889 (A/G). Higher mean serum PSA levels were significantly associated with an increase in the number of the rs7608798 C allele (p for trend = 0.02). A stratified analysis by age groups demonstrated that PSA levels had positive significant trends with the numbers of the minor alleles of rs3788979 or rs7608798 in the oldest group (men aged between 60 and 69) (p for trend=0.004 for rs3788979 and p for trend=0.001 for rs7608798). Haplotype analysis showed that the C-A (rs7608798-rs2268889) haplotype was significantly associated with increased PSA levels (p=0.006), compared with the most common haplotype, T-A. In summary, our study suggests that DPP4 genetic variants influence baseline PSA levels, especially in men aged between 60 and 69. Nagoya University 2013-02 /pmc/articles/PMC4345699/ /pubmed/23544270 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper HIGASHIBATA, TAKAHIRO NAITO, MARIKO MORI, ATSUYOSHI OZAWA, NORIYO FURUTA, MASATOSHI TSUCHIYA, RUMI KOYAMA, ERINA MORITA, EMI KAWAI, SAYO OKADA, RIEKO YIN, GUANG WAKAI, KENJI HAMAJIMA, NOBUYUKI DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title |
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title_full |
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title_fullStr |
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title_full_unstemmed |
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title_short |
DPP4 GENETIC VARIANTS INFLUENCE BASELINE PROSTATE-SPECIFIC ANTIGEN LEVELS: THE J-MICC STUDY |
title_sort | dpp4 genetic variants influence baseline prostate-specific antigen levels: the j-micc study |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345699/ https://www.ncbi.nlm.nih.gov/pubmed/23544270 |
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