Cargando…

THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN

Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators of the sleep/wakefulness cycle. In addition, anatomica...

Descripción completa

Detalles Bibliográficos
Autores principales: INUTSUKA, AYUMU, YAMANAKA, AKIHIRO
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nagoya University 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345701/
https://www.ncbi.nlm.nih.gov/pubmed/23544265
_version_ 1782359610474102784
author INUTSUKA, AYUMU
YAMANAKA, AKIHIRO
author_facet INUTSUKA, AYUMU
YAMANAKA, AKIHIRO
author_sort INUTSUKA, AYUMU
collection PubMed
description Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators of the sleep/wakefulness cycle. In addition, anatomical studies of neural networks and analyses of transgenic mice have revealed integrated roles for orexin neurons in the coordination of emotion, energy homeostasis, and the reward system. A functional link between the limbic system and orexin neurons may be important for increasing vigilance in response to emotional stimuli. These findings suggest that orexin neurons relay information about an organism’s environment to maintain the proper amount of sleep and wakefulness in animals.
format Online
Article
Text
id pubmed-4345701
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Nagoya University
record_format MEDLINE/PubMed
spelling pubmed-43457012015-03-04 THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN INUTSUKA, AYUMU YAMANAKA, AKIHIRO Nagoya J Med Sci Invited Review Article Orexins, also known as hypocretins, are neuropeptides that are exclusively expressed by neurons in the lateral hypothalamic area. Although originally recognized as regulators of feeding behavior, orexins are now mainly regarded as key modulators of the sleep/wakefulness cycle. In addition, anatomical studies of neural networks and analyses of transgenic mice have revealed integrated roles for orexin neurons in the coordination of emotion, energy homeostasis, and the reward system. A functional link between the limbic system and orexin neurons may be important for increasing vigilance in response to emotional stimuli. These findings suggest that orexin neurons relay information about an organism’s environment to maintain the proper amount of sleep and wakefulness in animals. Nagoya University 2013-02 /pmc/articles/PMC4345701/ /pubmed/23544265 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Invited Review Article
INUTSUKA, AYUMU
YAMANAKA, AKIHIRO
THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title_full THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title_fullStr THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title_full_unstemmed THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title_short THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
title_sort regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin
topic Invited Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345701/
https://www.ncbi.nlm.nih.gov/pubmed/23544265
work_keys_str_mv AT inutsukaayumu theregulationofsleepandwakefulnessbythehypothalamicneuropeptideorexinhypocretin
AT yamanakaakihiro theregulationofsleepandwakefulnessbythehypothalamicneuropeptideorexinhypocretin
AT inutsukaayumu regulationofsleepandwakefulnessbythehypothalamicneuropeptideorexinhypocretin
AT yamanakaakihiro regulationofsleepandwakefulnessbythehypothalamicneuropeptideorexinhypocretin