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RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY
We conducted a retrospective comparison of the hemotoxicity of the sequential administration of 5-Fluorouracil (5-FU) prior to Nedaplatin (NDP) (FN therapy) and that of its reverse sequence (NF therapy) for gynecological malignancy. From February 2002 to November 2004, a total of 15 gynecological ma...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nagoya University
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345731/ https://www.ncbi.nlm.nih.gov/pubmed/25129987 |
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author | ITOH, YOSHIYUKI IKEDA, MITSURU HIRASAWA, NAOKI ISHIHARA, SHUNICHI OKUDA, TAKAHITO MURAO, TAKAYUKI KUBOTA, SEIJI OKADA, TOHRU NAGANAWA, SHINJI ISHIGAKI, TAKEO |
author_facet | ITOH, YOSHIYUKI IKEDA, MITSURU HIRASAWA, NAOKI ISHIHARA, SHUNICHI OKUDA, TAKAHITO MURAO, TAKAYUKI KUBOTA, SEIJI OKADA, TOHRU NAGANAWA, SHINJI ISHIGAKI, TAKEO |
author_sort | ITOH, YOSHIYUKI |
collection | PubMed |
description | We conducted a retrospective comparison of the hemotoxicity of the sequential administration of 5-Fluorouracil (5-FU) prior to Nedaplatin (NDP) (FN therapy) and that of its reverse sequence (NF therapy) for gynecological malignancy. From February 2002 to November 2004, a total of 15 gynecological malignancy patients were treated with radiation therapy combined with NDP and 5-FU. Of these 15 patients, 5 were treated with NF therapy, and 10 were treated with FN therapy. No significant differences were detected between the FN and NF groups with regard to white blood cell count (WBC), hemoglobin level (Hb), and platelet count. The results of this study do not show that the FN group has a lesser degree of hemotoxicity than the NF group. |
format | Online Article Text |
id | pubmed-4345731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Nagoya University |
record_format | MEDLINE/PubMed |
spelling | pubmed-43457312015-03-04 RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY ITOH, YOSHIYUKI IKEDA, MITSURU HIRASAWA, NAOKI ISHIHARA, SHUNICHI OKUDA, TAKAHITO MURAO, TAKAYUKI KUBOTA, SEIJI OKADA, TOHRU NAGANAWA, SHINJI ISHIGAKI, TAKEO Nagoya J Med Sci Original Paper We conducted a retrospective comparison of the hemotoxicity of the sequential administration of 5-Fluorouracil (5-FU) prior to Nedaplatin (NDP) (FN therapy) and that of its reverse sequence (NF therapy) for gynecological malignancy. From February 2002 to November 2004, a total of 15 gynecological malignancy patients were treated with radiation therapy combined with NDP and 5-FU. Of these 15 patients, 5 were treated with NF therapy, and 10 were treated with FN therapy. No significant differences were detected between the FN and NF groups with regard to white blood cell count (WBC), hemoglobin level (Hb), and platelet count. The results of this study do not show that the FN group has a lesser degree of hemotoxicity than the NF group. Nagoya University 2014-02 /pmc/articles/PMC4345731/ /pubmed/25129987 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper ITOH, YOSHIYUKI IKEDA, MITSURU HIRASAWA, NAOKI ISHIHARA, SHUNICHI OKUDA, TAKAHITO MURAO, TAKAYUKI KUBOTA, SEIJI OKADA, TOHRU NAGANAWA, SHINJI ISHIGAKI, TAKEO RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title | RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title_full | RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title_fullStr | RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title_full_unstemmed | RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title_short | RETROSPECTIVE CASE SERIES OF 15 PATIENTS TREATED WITH CHEMORADIATION USING 5-FU AND NEDAPLATIN FOR GYNECOLOGICAL MALIGNANCY: WITH REGARD TO HEMOTOXICITY |
title_sort | retrospective case series of 15 patients treated with chemoradiation using 5-fu and nedaplatin for gynecological malignancy: with regard to hemotoxicity |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345731/ https://www.ncbi.nlm.nih.gov/pubmed/25129987 |
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