Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing

Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an ast...

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Autores principales: Naccache, Samia N., Peggs, Karl S., Mattes, Frank M., Phadke, Rahul, Garson, Jeremy A., Grant, Paul, Samayoa, Erik, Federman, Scot, Miller, Steve, Lunn, Michael P., Gant, Vanya, Chiu, Charles Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345816/
https://www.ncbi.nlm.nih.gov/pubmed/25572898
http://dx.doi.org/10.1093/cid/ciu912
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author Naccache, Samia N.
Peggs, Karl S.
Mattes, Frank M.
Phadke, Rahul
Garson, Jeremy A.
Grant, Paul
Samayoa, Erik
Federman, Scot
Miller, Steve
Lunn, Michael P.
Gant, Vanya
Chiu, Charles Y.
author_facet Naccache, Samia N.
Peggs, Karl S.
Mattes, Frank M.
Phadke, Rahul
Garson, Jeremy A.
Grant, Paul
Samayoa, Erik
Federman, Scot
Miller, Steve
Lunn, Michael P.
Gant, Vanya
Chiu, Charles Y.
author_sort Naccache, Samia N.
collection PubMed
description Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
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spelling pubmed-43458162015-03-17 Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing Naccache, Samia N. Peggs, Karl S. Mattes, Frank M. Phadke, Rahul Garson, Jeremy A. Grant, Paul Samayoa, Erik Federman, Scot Miller, Steve Lunn, Michael P. Gant, Vanya Chiu, Charles Y. Clin Infect Dis Brief Reports Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade. Oxford University Press 2015-03-15 2015-01-07 /pmc/articles/PMC4345816/ /pubmed/25572898 http://dx.doi.org/10.1093/cid/ciu912 Text en © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Naccache, Samia N.
Peggs, Karl S.
Mattes, Frank M.
Phadke, Rahul
Garson, Jeremy A.
Grant, Paul
Samayoa, Erik
Federman, Scot
Miller, Steve
Lunn, Michael P.
Gant, Vanya
Chiu, Charles Y.
Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title_full Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title_fullStr Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title_full_unstemmed Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title_short Diagnosis of Neuroinvasive Astrovirus Infection in an Immunocompromised Adult With Encephalitis by Unbiased Next-Generation Sequencing
title_sort diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345816/
https://www.ncbi.nlm.nih.gov/pubmed/25572898
http://dx.doi.org/10.1093/cid/ciu912
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