MicroRNAs: new players in IBD

MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miR...

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Detalles Bibliográficos
Autores principales: Kalla, R, Ventham, N T, Kennedy, N A, Quintana, J F, Nimmo, E R, Buck, A H, Satsangi, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Recent Advances in Basic Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345829/
https://www.ncbi.nlm.nih.gov/pubmed/25475103
http://dx.doi.org/10.1136/gutjnl-2014-307891
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author Kalla, R
Ventham, N T
Kennedy, N A
Quintana, J F
Nimmo, E R
Buck, A H
Satsangi, J
author_facet Kalla, R
Ventham, N T
Kennedy, N A
Quintana, J F
Nimmo, E R
Buck, A H
Satsangi, J
author_sort Kalla, R
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
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spelling pubmed-43458292015-03-18 MicroRNAs: new players in IBD Kalla, R Ventham, N T Kennedy, N A Quintana, J F Nimmo, E R Buck, A H Satsangi, J Gut Recent Advances in Basic Science MicroRNAs (miRNAs) are small non-coding RNAs, 18–23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications. BMJ Publishing Group 2015-03 2014-12-04 /pmc/articles/PMC4345829/ /pubmed/25475103 http://dx.doi.org/10.1136/gutjnl-2014-307891 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Recent Advances in Basic Science
Kalla, R
Ventham, N T
Kennedy, N A
Quintana, J F
Nimmo, E R
Buck, A H
Satsangi, J
MicroRNAs: new players in IBD
title MicroRNAs: new players in IBD
title_full MicroRNAs: new players in IBD
title_fullStr MicroRNAs: new players in IBD
title_full_unstemmed MicroRNAs: new players in IBD
title_short MicroRNAs: new players in IBD
title_sort micrornas: new players in ibd
topic Recent Advances in Basic Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345829/
https://www.ncbi.nlm.nih.gov/pubmed/25475103
http://dx.doi.org/10.1136/gutjnl-2014-307891
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