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Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans
BACKGROUND: Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345860/ https://www.ncbi.nlm.nih.gov/pubmed/25655570 http://dx.doi.org/10.1161/JAHA.114.001224 |
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author | Fox, Ervin R. Musani, Solomon K. Samdarshi, Tandaw E. Taylor, Jared K. Beard, Walter L. Sarpong, Daniel F. Xanthakis, Vanessa McClendon, Eric E. Liebson, Philip R. Skelton, Thomas N. Butler, Kenneth R. Mosley, Thomas H. Taylor, Herman Vasan, Ramachandran S. |
author_facet | Fox, Ervin R. Musani, Solomon K. Samdarshi, Tandaw E. Taylor, Jared K. Beard, Walter L. Sarpong, Daniel F. Xanthakis, Vanessa McClendon, Eric E. Liebson, Philip R. Skelton, Thomas N. Butler, Kenneth R. Mosley, Thomas H. Taylor, Herman Vasan, Ramachandran S. |
author_sort | Fox, Ervin R. |
collection | PubMed |
description | BACKGROUND: Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables over time are associated with longitudinal increases in LVM and that such increase is associated with greater incidence of CVD. METHODS AND RESULTS: We investigated the clinical correlates of change in standardized logarithmically transformed‐LVM indexed to height2.7 (log‐LVMI) and its association with incident CVD in 606 African Americans (mean age 58±6 years, 66% women) who attended serial examinations 8 years apart. Log‐LVMI and clinical covariates were standardized within sex to obtain z scores for both visits. Standardized log‐LVMI was modeled using linear regression (correlates of change in standardized log‐LVMI) and Cox proportional hazards regression (incidence of CVD [defined as coronary heart disease, stroke, heart failure and intermittent claudication]). Baseline clinical correlates (standardized log‐LVM, BMI, systolic BP) and change in systolic BP over time were significantly associated with 8‐year change in standardized log‐LVMI. In prospective analysis, change in standardized LVM was significantly (P=0.0011) associated with incident CVD (hazards ratio per unit standard deviation change log‐LVMI 1.51, 95% CI 1.18 to 1.93). CONCLUSIONS: In our community‐based sample of African Americans, baseline BMI and BP, and change in BP on follow‐up were key determinants of increase in standardized log‐LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group. |
format | Online Article Text |
id | pubmed-4345860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43458602015-03-10 Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans Fox, Ervin R. Musani, Solomon K. Samdarshi, Tandaw E. Taylor, Jared K. Beard, Walter L. Sarpong, Daniel F. Xanthakis, Vanessa McClendon, Eric E. Liebson, Philip R. Skelton, Thomas N. Butler, Kenneth R. Mosley, Thomas H. Taylor, Herman Vasan, Ramachandran S. J Am Heart Assoc Original Research BACKGROUND: Though left ventricular mass (LVM) predicts cardiovascular events (CVD) and mortality in African Americans, limited data exists on factors contributing to change in LVM and its prognostic significance. We hypothesized that baseline blood pressure (BP) and body mass index (BMI) and change in these variables over time are associated with longitudinal increases in LVM and that such increase is associated with greater incidence of CVD. METHODS AND RESULTS: We investigated the clinical correlates of change in standardized logarithmically transformed‐LVM indexed to height2.7 (log‐LVMI) and its association with incident CVD in 606 African Americans (mean age 58±6 years, 66% women) who attended serial examinations 8 years apart. Log‐LVMI and clinical covariates were standardized within sex to obtain z scores for both visits. Standardized log‐LVMI was modeled using linear regression (correlates of change in standardized log‐LVMI) and Cox proportional hazards regression (incidence of CVD [defined as coronary heart disease, stroke, heart failure and intermittent claudication]). Baseline clinical correlates (standardized log‐LVM, BMI, systolic BP) and change in systolic BP over time were significantly associated with 8‐year change in standardized log‐LVMI. In prospective analysis, change in standardized LVM was significantly (P=0.0011) associated with incident CVD (hazards ratio per unit standard deviation change log‐LVMI 1.51, 95% CI 1.18 to 1.93). CONCLUSIONS: In our community‐based sample of African Americans, baseline BMI and BP, and change in BP on follow‐up were key determinants of increase in standardized log‐LVMI, which in turn carried an adverse prognosis, underscoring the need for greater control of BP and weight in this group. Blackwell Publishing Ltd 2015-02-05 /pmc/articles/PMC4345860/ /pubmed/25655570 http://dx.doi.org/10.1161/JAHA.114.001224 Text en © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Research Fox, Ervin R. Musani, Solomon K. Samdarshi, Tandaw E. Taylor, Jared K. Beard, Walter L. Sarpong, Daniel F. Xanthakis, Vanessa McClendon, Eric E. Liebson, Philip R. Skelton, Thomas N. Butler, Kenneth R. Mosley, Thomas H. Taylor, Herman Vasan, Ramachandran S. Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title | Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title_full | Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title_fullStr | Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title_full_unstemmed | Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title_short | Clinical Correlates and Prognostic Significance of Change in Standardized Left Ventricular Mass in a Community‐Based Cohort of African Americans |
title_sort | clinical correlates and prognostic significance of change in standardized left ventricular mass in a community‐based cohort of african americans |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345860/ https://www.ncbi.nlm.nih.gov/pubmed/25655570 http://dx.doi.org/10.1161/JAHA.114.001224 |
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