Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice

BACKGROUND: Cardiac dysfunction developing in response to chronic pressure overload is associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether deletion of tumor suppressor p53 in endothelial cells may prevent the transition from cardiac hypertrophy to heart failur...

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Detalles Bibliográficos
Autores principales: Gogiraju, Rajinikanth, Xu, Xingbo, Bochenek, Magdalena L., Steinbrecher, Julia H., Lehnart, Stephan E., Wenzel, Philip, Kessel, Michael, Zeisberg, Elisabeth M., Dobbelstein, Matthias, Schäfer, Katrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345879/
https://www.ncbi.nlm.nih.gov/pubmed/25713289
http://dx.doi.org/10.1161/JAHA.115.001770

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