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Commensal bacteria drive endogenous transformation and tumour stem cell marker expression through a bystander effect

OBJECTIVE: Commensal bacteria and innate immunity play a major role in the development of colorectal cancer (CRC). We propose that selected commensals polarise colon macrophages to produce endogenous mutagens that initiate chromosomal instability (CIN), lead to expression of progenitor and tumour st...

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Detalles Bibliográficos
Autores principales:	Wang, Xingmin, Yang, Yonghong, Huycke, Mark M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2015
Materias:	Gut Microbiota
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345889/ https://www.ncbi.nlm.nih.gov/pubmed/24906974 http://dx.doi.org/10.1136/gutjnl-2014-307213

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