Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases

Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neurop...

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Detalles Bibliográficos
Autores principales: Gardoni, Fabrizio, Bellone, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345909/
https://www.ncbi.nlm.nih.gov/pubmed/25784855
http://dx.doi.org/10.3389/fncel.2015.00025
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author Gardoni, Fabrizio
Bellone, Camilla
author_facet Gardoni, Fabrizio
Bellone, Camilla
author_sort Gardoni, Fabrizio
collection PubMed
description Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in striatal circuits.
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spelling pubmed-43459092015-03-17 Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases Gardoni, Fabrizio Bellone, Camilla Front Cell Neurosci Neuroscience Dopamine (DA) plays a major role in motor and cognitive functions as well as in reward processing by regulating glutamatergic inputs. In particular in the striatum the release of DA rapidly influences synaptic transmission modulating both AMPA and NMDA receptors. Several neurodegenerative and neuropsychiatric disorders, including Parkinson, Huntington and addiction-related diseases, manifest a dysregulation of glutamate and DA signaling. Here, we will focus our attention on the mechanisms underlying the modulation of the glutamatergic transmission by DA in striatal circuits. Frontiers Media S.A. 2015-03-02 /pmc/articles/PMC4345909/ /pubmed/25784855 http://dx.doi.org/10.3389/fncel.2015.00025 Text en Copyright © 2015 Gardoni and Bellone. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gardoni, Fabrizio
Bellone, Camilla
Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title_full Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title_fullStr Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title_full_unstemmed Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title_short Modulation of the glutamatergic transmission by Dopamine: a focus on Parkinson, Huntington and Addiction diseases
title_sort modulation of the glutamatergic transmission by dopamine: a focus on parkinson, huntington and addiction diseases
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345909/
https://www.ncbi.nlm.nih.gov/pubmed/25784855
http://dx.doi.org/10.3389/fncel.2015.00025
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