Cargando…

SAMHD1 prevents autoimmunity by maintaining genome stability

OBJECTIVES: The HIV restriction factor, SAMHD1 (SAM domain and HD domain-containing protein 1), is a triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs). Mutations in SAMHD1 cause Aicardi–Goutières syndrome (AGS), an inflammatory disorder that shares phenotypic similarity wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kretschmer, Stefanie, Wolf, Christine, König, Nadja, Staroske, Wolfgang, Guck, Jochen, Häusler, Martin, Luksch, Hella, Nguyen, Laura A, Kim, Baek, Alexopoulou, Dimitra, Dahl, Andreas, Rapp, Alexander, Cardoso, M Cristina, Shevchenko, Anna, Lee-Kirsch, Min Ae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2015
Materias:	Electronic Pages
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4345975/ https://www.ncbi.nlm.nih.gov/pubmed/24445253 http://dx.doi.org/10.1136/annrheumdis-2013-204845

Ejemplares similares

Intracranial thrombectomy using the Solitaire stent: a historical vignette
por: Pérez, Marta Aguilar, et al.
Publicado: (2012)

Mapping tobacco industry strategies in South East Asia for action planning and surveillance
por: Stillman, F, et al.
Publicado: (2008)

Endovascular recanalization for chronic symptomatic middle cerebral artery total occlusion
por: Ma, Ning, et al.
Publicado: (2013)

Characterisation of the pharmacokinetics of ethinylestradiol and drospirenone in extended-cycle regimens: population pharmacokinetic analysis from a randomised Phase III study
por: Reif, Stefanie, et al.
Publicado: (2013)

Double-barrel extracranial–intracranial bypass surgery followed by endovascular carotid artery occlusion in a patient with an extracranial giant internal carotid artery aneurysm due to Ehlers–Danlos syndrome
por: Perrin, Jason Michael, et al.
Publicado: (2013)

Corrections
Publicado: (2011)

Diagnostic delay in patients with rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis: results from the Danish nationwide DANBIO registry
por: Sørensen, Jan, et al.
Publicado: (2015)

“There are bugs in condoms”: Tanzanian close-to-community providers' ability to offer effective adolescent reproductive health services
por: Dusabe, John, et al.
Publicado: (2015)

Risk factors for unplanned pregnancy among young women in Tanzania
por: Calvert, Clara, et al.
Publicado: (2013)

Correction: Discontinuation of adalimumab after achieving remission in patients with established rheumatoid arthritis: 1-year outcome of the HONOR study
Publicado: (2016)

A ‘busy day’ effect on perinatal complications of delivery on weekends: a retrospective cohort study
por: Snowden, Jonathan M, et al.
Publicado: (2017)

Explanation and elaboration of the SQUIRE (Standards for Quality Improvement Reporting Excellence) Guidelines, V.2.0: examples of SQUIRE elements in the healthcare improvement literature
por: Goodman, Daisy, et al.
Publicado: (2016)

Evaluating the use of cytosine arabinoside for treatment for recurrent canine steroid-responsive meningitis-arteritis
por: Günther, Christian, et al.
Publicado: (2020)

Is the production of a Covid-19 vaccine using transformed Pasteurella plausible?
por: Rycroft, Andrew N, et al.
Publicado: (2020)

Aung Myint and trevor Jones respond
por: Myint, Aung, et al.
Publicado: (2020)

Effects of probiotic Lactobacillus acidophilus D2/CSL (CECT 4529) on the nutritional and health status of boxer dogs
por: Marelli, Stefano Paolo, et al.
Publicado: (2020)

Remote prescribing guidance extended
Publicado: (2020)

Randomised clinical non-inferiority trial comparing two formulations of desoxycortone pivalate for the treatment of canine primary hypoadrenocorticism
por: Farr, Hayley, et al.
Publicado: (2020)

Covid-19: 10 lessons from young farm vets
Publicado: (2020)

Tighter wildlife disease monitoring needed to prevent future pandemics
Publicado: (2020)

Vet labs working on Covid-19 research
Publicado: (2020)

Canine behaviour problems in Brazil: a review of 180 referral cases
por: Ramos, Daniela, et al.
Publicado: (2020)

Prednisolone therapy for chronic hepatitis in English springer spaniels: a prospective study of 12 cases
por: Bayton, William, et al.
Publicado: (2020)

Confidence of veterinary surgeons in the United Kingdom in treating and diagnosing exotic pet species
por: Wills, Alison, et al.
Publicado: (2020)

Hair arsenic level in rice-based diet-fed Staffordshire bull terriers
por: Rosendahl, Sarah, et al.
Publicado: (2020)

Vaquitas (Phocoena sinus) continue to die from bycatch not pollutants
por: Gulland, Frances, et al.
Publicado: (2020)

Ophthalmology of clinically normal alpacas (Vicugna pacos) in the United Kingdom: a cross-sectional study
por: Faulkner, Josephine, et al.
Publicado: (2020)

Characterising keratometry in different dog breeds using an automatic handheld keratometer
por: Kawasaki, Minae, et al.
Publicado: (2020)

Controlled field study evaluating the clinical efficacy of a topical formulation containing emodepside and praziquantel in the treatment of natural cat aelurostrongylosis
por: Crisi, Paolo Emidio, et al.
Publicado: (2020)

Evaluation of lamb colostrum supplements
por: Bond, Cherry
Publicado: (2020)

Risk-based surveillance for bluetongue virus in cattle on the south coast of England in 2017 and 2018
por: Grace, Katherine Elinor Felicity, et al.
Publicado: (2020)

Modification of empirical antimicrobial regimens in large animal medicine
por: Redding, Laurel, et al.
Publicado: (2020)

Presence of pathogenic bacteria in faeces from dogs fed raw meat-based diets or dry kibble
por: Runesvärd, Ellinor, et al.
Publicado: (2020)

Clinical management of lipomas in dogs under primary care in the UK
por: Pegram, Camilla Leonie, et al.
Publicado: (2020)

Association between breed and renal biomarkers of glomerular filtration rate in dogs
por: Coyne, Michael, et al.
Publicado: (2020)

Insulin Autoimmune Syndrome Induced by α–Lipoic Acid in a Caucasian Woman: Case Report
por: Bresciani, Enrico, et al.
Publicado: (2011)

Comment on: Olsson et al. High Levels of Education Are Associated With an Increased Risk of Latent Autoimmune Diabetes in Adults: Results From the Nord-Trøndelag Health Study. Diabetes Care 2011;34:102–107
por: Sawicki, Peter T., et al.
Publicado: (2011)

Response to Comment on: Olsson et al. High Levels of Education Are Associated With an Increased Risk of Latent Autoimmune Diabetes in Adults: Results From the Nord-Trøndelag Health Study. Diabetes Care 2011;34:102–107
por: Olsson, Lisa, et al.
Publicado: (2011)

RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA
por: Wolf, Christine, et al.
Publicado: (2016)

Mouse SAMHD1 Has Antiretroviral Activity and Suppresses a Spontaneous Cell-Intrinsic Antiviral Response
por: Behrendt, Rayk, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_03lisbi7atffri69gvvi26vnci