Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells

Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation of...

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Autores principales: Irimie, Alexandra Iulia, Braicu, Cornelia, Zanoaga, Oana, Pileczki, Valentina, Gherman, Claudia, Berindan-Neagoe, Ioana, Campian, Radu Septimiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346003/
https://www.ncbi.nlm.nih.gov/pubmed/25759589
http://dx.doi.org/10.2147/OTT.S78358
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author Irimie, Alexandra Iulia
Braicu, Cornelia
Zanoaga, Oana
Pileczki, Valentina
Gherman, Claudia
Berindan-Neagoe, Ioana
Campian, Radu Septimiu
author_facet Irimie, Alexandra Iulia
Braicu, Cornelia
Zanoaga, Oana
Pileczki, Valentina
Gherman, Claudia
Berindan-Neagoe, Ioana
Campian, Radu Septimiu
author_sort Irimie, Alexandra Iulia
collection PubMed
description Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation of apoptosis and autophagy, in response to EGCG exposure in SSC-4 cells. Treatment with EGCG activates the expression of the BAD, BAK, FAS, IGF1R, WNT11, and ZEB1 genes and inhibits CASP8, MYC, and TP53. All of these results suggest that EGCG has an excellent potential to become a therapeutic compound for patients with OSCC, by inducing tumor cell death via apoptosis and autophagy.
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spelling pubmed-43460032015-03-10 Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells Irimie, Alexandra Iulia Braicu, Cornelia Zanoaga, Oana Pileczki, Valentina Gherman, Claudia Berindan-Neagoe, Ioana Campian, Radu Septimiu Onco Targets Ther Original Research Epigallocatechin-3-gallate (EGCG) is the major bioactive component of green tea. Our experimental data indicated that EGCG treatment suppresses cell proliferation of SSC-4 human oral squamous cell carcinoma (OSCC), the effect being dose- and time-dependent. In parallel was observed the activation of apoptosis and autophagy, in response to EGCG exposure in SSC-4 cells. Treatment with EGCG activates the expression of the BAD, BAK, FAS, IGF1R, WNT11, and ZEB1 genes and inhibits CASP8, MYC, and TP53. All of these results suggest that EGCG has an excellent potential to become a therapeutic compound for patients with OSCC, by inducing tumor cell death via apoptosis and autophagy. Dove Medical Press 2015-02-20 /pmc/articles/PMC4346003/ /pubmed/25759589 http://dx.doi.org/10.2147/OTT.S78358 Text en © 2015 Irimie et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Irimie, Alexandra Iulia
Braicu, Cornelia
Zanoaga, Oana
Pileczki, Valentina
Gherman, Claudia
Berindan-Neagoe, Ioana
Campian, Radu Septimiu
Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title_full Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title_fullStr Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title_full_unstemmed Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title_short Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer SSC-4 cells
title_sort epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral cancer ssc-4 cells
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346003/
https://www.ncbi.nlm.nih.gov/pubmed/25759589
http://dx.doi.org/10.2147/OTT.S78358
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