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Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis

Biological markers, i.e., biomarkers, in lung tissue may make it possible to connect cell biological phenomena to the pathogenetic mechanisms in idiopathic pulmonary fibrosis (IPF). This review focuses on the lung tissue biomarkers, which have been compared with relevant clinical endpoints or with t...

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Detalles Bibliográficos
Autores principales: Kaarteenaho, Riitta, Lappi-Blanco, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346107/
https://www.ncbi.nlm.nih.gov/pubmed/25733981
http://dx.doi.org/10.1186/s13069-015-0020-2
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author Kaarteenaho, Riitta
Lappi-Blanco, Elisa
author_facet Kaarteenaho, Riitta
Lappi-Blanco, Elisa
author_sort Kaarteenaho, Riitta
collection PubMed
description Biological markers, i.e., biomarkers, in lung tissue may make it possible to connect cell biological phenomena to the pathogenetic mechanisms in idiopathic pulmonary fibrosis (IPF). This review focuses on the lung tissue biomarkers, which have been compared with relevant clinical endpoints or with the most common differential diagnostic lung diseases. In addition, studies conducted on lung tissue samples and investigated by transcriptomic or proteomic methodologies have been included. Several studies have observed changes in alveolar epithelium and extracellular matrix supporting the current hypotheses of the pathogenesis of IPF. In many studies, however, alterations in inflammatory cells have been revealed, a phenomenon not currently incorporated into pathogenetic theories. Combining lung tissue material with other non-solid organs with clinically meaningful endpoints may prove to be the most beneficial approach in the search for non-invasive biomarkers.
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spelling pubmed-43461072015-03-03 Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis Kaarteenaho, Riitta Lappi-Blanco, Elisa Fibrogenesis Tissue Repair Review Biological markers, i.e., biomarkers, in lung tissue may make it possible to connect cell biological phenomena to the pathogenetic mechanisms in idiopathic pulmonary fibrosis (IPF). This review focuses on the lung tissue biomarkers, which have been compared with relevant clinical endpoints or with the most common differential diagnostic lung diseases. In addition, studies conducted on lung tissue samples and investigated by transcriptomic or proteomic methodologies have been included. Several studies have observed changes in alveolar epithelium and extracellular matrix supporting the current hypotheses of the pathogenesis of IPF. In many studies, however, alterations in inflammatory cells have been revealed, a phenomenon not currently incorporated into pathogenetic theories. Combining lung tissue material with other non-solid organs with clinically meaningful endpoints may prove to be the most beneficial approach in the search for non-invasive biomarkers. BioMed Central 2015-03-02 /pmc/articles/PMC4346107/ /pubmed/25733981 http://dx.doi.org/10.1186/s13069-015-0020-2 Text en © Kaarteenaho and Lappi-Blanco; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Kaarteenaho, Riitta
Lappi-Blanco, Elisa
Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title_full Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title_fullStr Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title_full_unstemmed Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title_short Tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
title_sort tissue is an issue in the search for biomarkers in idiopathic pulmonary fibrosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346107/
https://www.ncbi.nlm.nih.gov/pubmed/25733981
http://dx.doi.org/10.1186/s13069-015-0020-2
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