Early transduction produces highly functional chimeric antigen receptor-modified virus-specific T-cells with central memory markers: a Production Assistant for Cell Therapy (PACT) translational application

BACKGROUND: Virus-specific T-cells (VSTs) proliferate exponentially after adoptive transfer into hematopoietic stem cell transplant (HSCT) recipients, eliminate virus infections, then persist and provide long-term protection from viral disease. If VSTs behaved similarly when modified with tumor-spec...

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Detalles Bibliográficos
Autores principales: Sun, Jiali, Huye, Leslie E, Lapteva, Natalia, Mamonkin, Maksim, Hiregange, Manasa, Ballard, Brandon, Dakhova, Olga, Raghavan, Darshana, Durett, April G, Perna, Serena K, Omer, Bilal, Rollins, Lisa A, Leen, Ann M, Vera, Juan F, Dotti, Gianpietro, Gee, Adrian P, Brenner, Malcolm K, Myers, Douglas G, Rooney, Cliona M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346112/
https://www.ncbi.nlm.nih.gov/pubmed/25734008
http://dx.doi.org/10.1186/s40425-015-0049-1

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