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CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Molecular mechanisms that maintain lineage integrity of helper T cells are largely unknown. Here we show histone deacetylases (HDAC) 1 and 2 as crucial regulators of this process. Loss of HDAC1 and HDAC2 during late T cell development led to the appearance of MHC class II-selected CD4(+) helper T ce...

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Detalles Bibliográficos
Autores principales:	Boucheron, Nicole, Tschismarov, Roland, Goeschl, Lisa, Moser, Mirjam A., Lagger, Sabine, Sakaguchi, Shinya, Winter, Mircea, Lenz, Florian, Vitko, Dijana, Breitwieser, Florian P., Müller, Lena, Hassan, Hammad, Bennett, Keiryn L., Colinge, Jacques, Schreiner, Wolfgang, Egawa, Takeshi, Taniuchi, Ichiro, Matthias, Patrick, Seiser, Christian, Ellmeier, Wilfried
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346201/ https://www.ncbi.nlm.nih.gov/pubmed/24681565 http://dx.doi.org/10.1038/ni.2864

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