Mixed nanomicelles as potential carriers for systemic delivery of Z-GP-Dox, an FAPα-based doxorubicin prodrug: formulation and pharmacokinetic evaluation

Z-GP-Dox, the FAPα (fibroblast activation protein-α)-based doxorubicin prodrug, demonstrates excellent tumor targeting effects and a favorable toxicokinetic profile. However, the insoluble nature of Z-GP-Dox becomes a significant barrier to drug administration, particularly when it comes to the clin...

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Detalles Bibliográficos
Autores principales: Zhang, Yuchen, Zhang, Xingwang, Liu, Hongming, Cai, Shaohui, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346364/
https://www.ncbi.nlm.nih.gov/pubmed/25759584
http://dx.doi.org/10.2147/IJN.S75954

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