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Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping

Abnormal metabolism has been reported in bipolar disorder, however these studies have been limited to specific regions of the brain. To investigate whole-brain changes potentially associated with these processes, we applied a magnetic resonance imaging technique novel to psychiatric research, quanti...

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Autores principales: Johnson, Casey P., Follmer, Robin L., Oguz, Ipek, Warren, Lois A., Christensen, Gary E., Fiedorowicz, Jess G., Magnotta, Vincent A., Wemmie, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346383/
https://www.ncbi.nlm.nih.gov/pubmed/25560762
http://dx.doi.org/10.1038/mp.2014.157
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author Johnson, Casey P.
Follmer, Robin L.
Oguz, Ipek
Warren, Lois A.
Christensen, Gary E.
Fiedorowicz, Jess G.
Magnotta, Vincent A.
Wemmie, John A.
author_facet Johnson, Casey P.
Follmer, Robin L.
Oguz, Ipek
Warren, Lois A.
Christensen, Gary E.
Fiedorowicz, Jess G.
Magnotta, Vincent A.
Wemmie, John A.
author_sort Johnson, Casey P.
collection PubMed
description Abnormal metabolism has been reported in bipolar disorder, however these studies have been limited to specific regions of the brain. To investigate whole-brain changes potentially associated with these processes, we applied a magnetic resonance imaging technique novel to psychiatric research, quantitative mapping of T1 relaxation in the rotating frame (T1ρ). This method is sensitive to proton chemical exchange, which is affected by pH, metabolite concentrations, and cellular density with high spatial resolution relative to alternative techniques such as magnetic resonance spectroscopy and positron emission tomography. Study participants included 15 patients with bipolar I disorder in the euthymic state and 25 normal controls balanced for age and gender. T1ρ maps were generated and compared between the bipolar and control groups using voxel-wise and regional analyses. T1ρ values were found to be elevated in the cerebral white matter and cerebellum in the bipolar group. However, volumes of these areas were normal as measured by high-resolution T1- and T2-weighted magnetic resonance imaging. Interestingly, the cerebellar T1ρ abnormalities were normalized in participants receiving lithium treatment. These findings are consistent with metabolic or microstructural abnormalities in bipolar disorder and draw attention to roles of the cerebral white matter and cerebellum. This study highlights the potential utility of high-resolution T1ρ mapping in psychiatric research.
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spelling pubmed-43463832015-08-01 Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping Johnson, Casey P. Follmer, Robin L. Oguz, Ipek Warren, Lois A. Christensen, Gary E. Fiedorowicz, Jess G. Magnotta, Vincent A. Wemmie, John A. Mol Psychiatry Article Abnormal metabolism has been reported in bipolar disorder, however these studies have been limited to specific regions of the brain. To investigate whole-brain changes potentially associated with these processes, we applied a magnetic resonance imaging technique novel to psychiatric research, quantitative mapping of T1 relaxation in the rotating frame (T1ρ). This method is sensitive to proton chemical exchange, which is affected by pH, metabolite concentrations, and cellular density with high spatial resolution relative to alternative techniques such as magnetic resonance spectroscopy and positron emission tomography. Study participants included 15 patients with bipolar I disorder in the euthymic state and 25 normal controls balanced for age and gender. T1ρ maps were generated and compared between the bipolar and control groups using voxel-wise and regional analyses. T1ρ values were found to be elevated in the cerebral white matter and cerebellum in the bipolar group. However, volumes of these areas were normal as measured by high-resolution T1- and T2-weighted magnetic resonance imaging. Interestingly, the cerebellar T1ρ abnormalities were normalized in participants receiving lithium treatment. These findings are consistent with metabolic or microstructural abnormalities in bipolar disorder and draw attention to roles of the cerebral white matter and cerebellum. This study highlights the potential utility of high-resolution T1ρ mapping in psychiatric research. 2015-01-06 2015-02 /pmc/articles/PMC4346383/ /pubmed/25560762 http://dx.doi.org/10.1038/mp.2014.157 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Johnson, Casey P.
Follmer, Robin L.
Oguz, Ipek
Warren, Lois A.
Christensen, Gary E.
Fiedorowicz, Jess G.
Magnotta, Vincent A.
Wemmie, John A.
Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title_full Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title_fullStr Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title_full_unstemmed Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title_short Brain Abnormalities in Bipolar Disorder Detected by Quantitative T1ρ Mapping
title_sort brain abnormalities in bipolar disorder detected by quantitative t1ρ mapping
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346383/
https://www.ncbi.nlm.nih.gov/pubmed/25560762
http://dx.doi.org/10.1038/mp.2014.157
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