The sheddase ADAM10 is a potent modulator of prion disease

The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease...

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Detalles Bibliográficos
Autores principales: Altmeppen, Hermann C, Prox, Johannes, Krasemann, Susanne, Puig, Berta, Kruszewski, Katharina, Dohler, Frank, Bernreuther, Christian, Hoxha, Ana, Linsenmeier, Luise, Sikorska, Beata, Liberski, Pawel P, Bartsch, Udo, Saftig, Paul, Glatzel, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346534/
https://www.ncbi.nlm.nih.gov/pubmed/25654651
http://dx.doi.org/10.7554/eLife.04260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346534/
https://www.ncbi.nlm.nih.gov/pubmed/25654651
http://dx.doi.org/10.7554/eLife.04260

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