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Snooker Structure-Based Pharmacophore Model Explains Differences in Agonist and Blocker Binding to Bitter Receptor hTAS2R39

The human bitter taste receptor hTAS2R39 can be activated by many dietary (iso)flavonoids. Furthermore, hTAS2R39 activity can be blocked by 6-methoxyflavanones, 4’-fluoro-6-methoxyflavanone in particular. A structure-based pharmacophore model of the hTAS2R39 binding pocket was built using Snooker so...

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Detalles Bibliográficos
Autores principales:	Roland, Wibke S. U., Sanders, Marijn P. A., van Buren, Leo, Gouka, Robin J., Gruppen, Harry, Vincken, Jean-Paul, Ritschel, Tina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346584/ https://www.ncbi.nlm.nih.gov/pubmed/25729848 http://dx.doi.org/10.1371/journal.pone.0118200

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