CEACAM1 induces B-cell survival and is essential for protective antiviral antibody production

B cells are essential for antiviral immune defence because they produce neutralizing antibodies, present antigen and maintain the lymphoid architecture. Here we show that intrinsic signalling of CEACAM1 is essential for generating efficient B-cell responses. Although CEACAM1 exerts limited influence...

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Detalles Bibliográficos
Autores principales: Khairnar, Vishal, Duhan, Vikas, Maney, Sathish Kumar, Honke, Nadine, Shaabani, Namir, Pandyra, Aleksandra A., Seifert, Marc, Pozdeev, Vitaly, Xu, Haifeng C., Sharma, Piyush, Baldin, Fabian, Marquardsen, Florian, Merches, Katja, Lang, Elisabeth, Kirschning, Carsten, Westendorf, Astrid M., Häussinger, Dieter, Lang, Florian, Dittmer, Ulf, Küppers, Ralf, Recher, Mike, Hardt, Cornelia, Scheffrahn, Inka, Beauchemin, Nicole, Göthert, Joachim R., Singer, Bernhard B., Lang, Philipp A., Lang, Karl S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346637/
https://www.ncbi.nlm.nih.gov/pubmed/25692415
http://dx.doi.org/10.1038/ncomms7217

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