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Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study
Since alkaline substances can rapidly penetrate into the cornea and subsequently damage limbal stem cells, another source of stem cells may be necessary to reconstruct the ocular surface. Omentum has some such characteristics like ability to regenerate tissue as well as anti-inflammatory capacity. P...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medical Hypothesis, Discovery & Innovation Ophthalmology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346679/ https://www.ncbi.nlm.nih.gov/pubmed/25738161 |
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author | Shadmani, Athar Kazemi, Kourosh Khalili, Mohammad Reza Eghtedari, Masoomeh |
author_facet | Shadmani, Athar Kazemi, Kourosh Khalili, Mohammad Reza Eghtedari, Masoomeh |
author_sort | Shadmani, Athar |
collection | PubMed |
description | Since alkaline substances can rapidly penetrate into the cornea and subsequently damage limbal stem cells, another source of stem cells may be necessary to reconstruct the ocular surface. Omentum has some such characteristics like ability to regenerate tissue as well as anti-inflammatory capacity. Presence of adult stem cells and pluripotent embryonic cell markers make it suitable in wound healing; therefore, it seems reasonable to evaluate whether omentum can be helpful to restoration of ocular surface in severe alkaline burn. In this experimental trial, two groups of dogs (5 in each) were assigned. Following ethics approval, ocular surface alkaline burn was induced in both groups by placing filter papers soaked with NaOH (0.5 mol/l) on the cornea of one eye. Subsequently, group 1 (n=5) was treated only by conventional therapy; group 2 (n=5) was treated with omental elongation and transposition to the injured eye immediately following injury. Both groups were followed for six months. Ocular surface was evaluated by slit lamp microscope and corneal clarity was assessed and graded. At the end of six months, corneal opacity and vascularization were significantly reduced in group 2 (p-values of 0.009, 0.049, and 0.032 for corneal opacity, fluorescein staining, and vascularization grades, respectively). We have concluded that transposition of omental pedicle may be an effective treatment for severe ocular surface alkaline burn although more studies might be required. |
format | Online Article Text |
id | pubmed-4346679 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medical Hypothesis, Discovery & Innovation Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-43466792015-03-03 Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study Shadmani, Athar Kazemi, Kourosh Khalili, Mohammad Reza Eghtedari, Masoomeh Med Hypothesis Discov Innov Ophthalmol Original Article Since alkaline substances can rapidly penetrate into the cornea and subsequently damage limbal stem cells, another source of stem cells may be necessary to reconstruct the ocular surface. Omentum has some such characteristics like ability to regenerate tissue as well as anti-inflammatory capacity. Presence of adult stem cells and pluripotent embryonic cell markers make it suitable in wound healing; therefore, it seems reasonable to evaluate whether omentum can be helpful to restoration of ocular surface in severe alkaline burn. In this experimental trial, two groups of dogs (5 in each) were assigned. Following ethics approval, ocular surface alkaline burn was induced in both groups by placing filter papers soaked with NaOH (0.5 mol/l) on the cornea of one eye. Subsequently, group 1 (n=5) was treated only by conventional therapy; group 2 (n=5) was treated with omental elongation and transposition to the injured eye immediately following injury. Both groups were followed for six months. Ocular surface was evaluated by slit lamp microscope and corneal clarity was assessed and graded. At the end of six months, corneal opacity and vascularization were significantly reduced in group 2 (p-values of 0.009, 0.049, and 0.032 for corneal opacity, fluorescein staining, and vascularization grades, respectively). We have concluded that transposition of omental pedicle may be an effective treatment for severe ocular surface alkaline burn although more studies might be required. Medical Hypothesis, Discovery & Innovation Ophthalmology 2014 /pmc/articles/PMC4346679/ /pubmed/25738161 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Shadmani, Athar Kazemi, Kourosh Khalili, Mohammad Reza Eghtedari, Masoomeh Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title | Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title_full | Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title_fullStr | Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title_full_unstemmed | Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title_short | Omental Transposition in Treatment of Severe Ocular Surface Alkaline Burn: An Experimental Study |
title_sort | omental transposition in treatment of severe ocular surface alkaline burn: an experimental study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346679/ https://www.ncbi.nlm.nih.gov/pubmed/25738161 |
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