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BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease

Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that co...

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Autores principales: Nakanishi, Atsuko, Minami, Akari, Kitagishi, Yasuko, Ogura, Yasunori, Matsuda, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346871/
https://www.ncbi.nlm.nih.gov/pubmed/25636033
http://dx.doi.org/10.3390/ijms16022879
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author Nakanishi, Atsuko
Minami, Akari
Kitagishi, Yasuko
Ogura, Yasunori
Matsuda, Satoru
author_facet Nakanishi, Atsuko
Minami, Akari
Kitagishi, Yasuko
Ogura, Yasunori
Matsuda, Satoru
author_sort Nakanishi, Atsuko
collection PubMed
description Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field.
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spelling pubmed-43468712015-04-03 BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease Nakanishi, Atsuko Minami, Akari Kitagishi, Yasuko Ogura, Yasunori Matsuda, Satoru Int J Mol Sci Review Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field. MDPI 2015-01-28 /pmc/articles/PMC4346871/ /pubmed/25636033 http://dx.doi.org/10.3390/ijms16022879 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nakanishi, Atsuko
Minami, Akari
Kitagishi, Yasuko
Ogura, Yasunori
Matsuda, Satoru
BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title_full BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title_fullStr BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title_full_unstemmed BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title_short BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
title_sort brca1 and p53 tumor suppressor molecules in alzheimer’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346871/
https://www.ncbi.nlm.nih.gov/pubmed/25636033
http://dx.doi.org/10.3390/ijms16022879
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