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BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease
Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that co...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346871/ https://www.ncbi.nlm.nih.gov/pubmed/25636033 http://dx.doi.org/10.3390/ijms16022879 |
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author | Nakanishi, Atsuko Minami, Akari Kitagishi, Yasuko Ogura, Yasunori Matsuda, Satoru |
author_facet | Nakanishi, Atsuko Minami, Akari Kitagishi, Yasuko Ogura, Yasunori Matsuda, Satoru |
author_sort | Nakanishi, Atsuko |
collection | PubMed |
description | Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field. |
format | Online Article Text |
id | pubmed-4346871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43468712015-04-03 BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease Nakanishi, Atsuko Minami, Akari Kitagishi, Yasuko Ogura, Yasunori Matsuda, Satoru Int J Mol Sci Review Tumor suppressor molecules play a pivotal role in regulating DNA repair, cell proliferation, and cell death, which are also important processes in the pathogenesis of Alzheimer’s disease. Alzheimer’s disease is the most common neurodegenerative disorder, however, the precise molecular events that control the death of neuronal cells are unclear. Recently, a fundamental role for tumor suppressor molecules in regulating neurons in Alzheimer’s disease was highlighted. Generally, onset of neurodegenerative diseases including Alzheimer’s disease may be delayed with use of dietary neuro-protective agents against oxidative stresses. Studies suggest that dietary antioxidants are also beneficial for brain health in reducing disease-risk and in slowing down disease-progression. We summarize research advances in dietary regulation for the treatment of Alzheimer’s disease with a focus on its modulatory roles in BRCA1 and p53 tumor suppressor expression, in support of further therapeutic research in this field. MDPI 2015-01-28 /pmc/articles/PMC4346871/ /pubmed/25636033 http://dx.doi.org/10.3390/ijms16022879 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nakanishi, Atsuko Minami, Akari Kitagishi, Yasuko Ogura, Yasunori Matsuda, Satoru BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title | BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title_full | BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title_fullStr | BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title_full_unstemmed | BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title_short | BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease |
title_sort | brca1 and p53 tumor suppressor molecules in alzheimer’s disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346871/ https://www.ncbi.nlm.nih.gov/pubmed/25636033 http://dx.doi.org/10.3390/ijms16022879 |
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