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Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae

Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms...

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Autores principales: Zhang, Jingxiao, Li, Yan, Chen, Su-Shing, Zhang, Lilei, Wang, Jinghui, Yang, Yinfeng, Zhang, Shuwei, Pan, Yanqiu, Wang, Yonghua, Yang, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346873/
https://www.ncbi.nlm.nih.gov/pubmed/25636035
http://dx.doi.org/10.3390/ijms16022913
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author Zhang, Jingxiao
Li, Yan
Chen, Su-Shing
Zhang, Lilei
Wang, Jinghui
Yang, Yinfeng
Zhang, Shuwei
Pan, Yanqiu
Wang, Yonghua
Yang, Ling
author_facet Zhang, Jingxiao
Li, Yan
Chen, Su-Shing
Zhang, Lilei
Wang, Jinghui
Yang, Yinfeng
Zhang, Shuwei
Pan, Yanqiu
Wang, Yonghua
Yang, Ling
author_sort Zhang, Jingxiao
collection PubMed
description Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-κB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations.
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spelling pubmed-43468732015-04-03 Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae Zhang, Jingxiao Li, Yan Chen, Su-Shing Zhang, Lilei Wang, Jinghui Yang, Yinfeng Zhang, Shuwei Pan, Yanqiu Wang, Yonghua Yang, Ling Int J Mol Sci Article Inflammation is a hallmark of many diseases like diabetes, cancers, atherosclerosis and arthritis. Thus, lots of concerns have been raised toward developing novel anti-inflammatory agents. Many alternative herbal medicines possess excellent anti-inflammatory properties, yet their precise mechanisms of action are yet to be elucidated. Here, a novel systems pharmacology approach based on a large number of chemical, biological and pharmacological data was developed and exemplified by a probe herb Folium Eriobotryae, a widely used clinical anti-inflammatory botanic drug. The results show that 11 ingredients of this herb with favorable pharmacokinetic properties are predicted as active compounds for anti-inflammatory treatment. In addition, via systematic network analyses, their targets are identified to be 43 inflammation-associated proteins including especially COX2, ALOX5, PPARG, TNF and RELA that are mainly involved in the mitogen-activated protein kinase (MAPK) signaling pathway, the rheumatoid arthritis pathway and NF-κB signaling pathway. All these demonstrate that the integrated systems pharmacology method provides not only an effective tool to illustrate the anti-inflammatory mechanisms of herbs, but also a new systems-based approach for drug discovery from, but not limited to, herbs, especially when combined with further experimental validations. MDPI 2015-01-28 /pmc/articles/PMC4346873/ /pubmed/25636035 http://dx.doi.org/10.3390/ijms16022913 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Jingxiao
Li, Yan
Chen, Su-Shing
Zhang, Lilei
Wang, Jinghui
Yang, Yinfeng
Zhang, Shuwei
Pan, Yanqiu
Wang, Yonghua
Yang, Ling
Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title_full Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title_fullStr Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title_full_unstemmed Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title_short Systems Pharmacology Dissection of the Anti-Inflammatory Mechanism for the Medicinal Herb Folium Eriobotryae
title_sort systems pharmacology dissection of the anti-inflammatory mechanism for the medicinal herb folium eriobotryae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346873/
https://www.ncbi.nlm.nih.gov/pubmed/25636035
http://dx.doi.org/10.3390/ijms16022913
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