A Time to Kill: Targeting Apoptosis in Cancer

The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulatio...

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Detalles Bibliográficos
Autores principales: Koff, Jean L., Ramachandiran, Sampath, Bernal-Mizrachi, Leon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346874/
https://www.ncbi.nlm.nih.gov/pubmed/25636036
http://dx.doi.org/10.3390/ijms16022942
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author Koff, Jean L.
Ramachandiran, Sampath
Bernal-Mizrachi, Leon
author_facet Koff, Jean L.
Ramachandiran, Sampath
Bernal-Mizrachi, Leon
author_sort Koff, Jean L.
collection PubMed
description The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy.
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spelling pubmed-43468742015-04-03 A Time to Kill: Targeting Apoptosis in Cancer Koff, Jean L. Ramachandiran, Sampath Bernal-Mizrachi, Leon Int J Mol Sci Review The process of apoptosis is essential for maintaining the physiologic balance between cell death and cell growth. This complex process is executed by two major pathways that participate in activating an executioner mechanism leading to chromatin disintegration and nuclear fragmentation. Dysregulation of these pathways often contributes to cancer development and resistance to cancer therapy. Here, we review the most recent discoveries in apoptosis regulation and possible mechanisms for resensitizing tumor cells to therapy. MDPI 2015-01-28 /pmc/articles/PMC4346874/ /pubmed/25636036 http://dx.doi.org/10.3390/ijms16022942 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Koff, Jean L.
Ramachandiran, Sampath
Bernal-Mizrachi, Leon
A Time to Kill: Targeting Apoptosis in Cancer
title A Time to Kill: Targeting Apoptosis in Cancer
title_full A Time to Kill: Targeting Apoptosis in Cancer
title_fullStr A Time to Kill: Targeting Apoptosis in Cancer
title_full_unstemmed A Time to Kill: Targeting Apoptosis in Cancer
title_short A Time to Kill: Targeting Apoptosis in Cancer
title_sort time to kill: targeting apoptosis in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346874/
https://www.ncbi.nlm.nih.gov/pubmed/25636036
http://dx.doi.org/10.3390/ijms16022942
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