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Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa
A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data wit...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346896/ https://www.ncbi.nlm.nih.gov/pubmed/25654226 http://dx.doi.org/10.3390/ijms16023298 |
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| author | Chen, Wu-Fu Yin, Chen-Ting Cheng, Ching-Hsiao Lu, Mei-Chin Fang, Lee-Shing Wang, Wei-Hsien Wen, Zhi-Hong Chen, Jih-Jung Wu, Yang-Chang Sung, Ping-Jyun |
| author_facet | Chen, Wu-Fu Yin, Chen-Ting Cheng, Ching-Hsiao Lu, Mei-Chin Fang, Lee-Shing Wang, Wei-Hsien Wen, Zhi-Hong Chen, Jih-Jung Wu, Yang-Chang Sung, Ping-Jyun |
| author_sort | Chen, Wu-Fu |
| collection | PubMed |
| description | A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC(50) value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds. |
| format | Online Article Text |
| id | pubmed-4346896 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-43468962015-04-03 Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa Chen, Wu-Fu Yin, Chen-Ting Cheng, Ching-Hsiao Lu, Mei-Chin Fang, Lee-Shing Wang, Wei-Hsien Wen, Zhi-Hong Chen, Jih-Jung Wu, Yang-Chang Sung, Ping-Jyun Int J Mol Sci Article A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4α-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC(50) value 4.21 μg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds. MDPI 2015-02-03 /pmc/articles/PMC4346896/ /pubmed/25654226 http://dx.doi.org/10.3390/ijms16023298 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Chen, Wu-Fu Yin, Chen-Ting Cheng, Ching-Hsiao Lu, Mei-Chin Fang, Lee-Shing Wang, Wei-Hsien Wen, Zhi-Hong Chen, Jih-Jung Wu, Yang-Chang Sung, Ping-Jyun Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title | Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title_full | Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title_fullStr | Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title_full_unstemmed | Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title_short | Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa |
| title_sort | norcembranoidal diterpenes from the cultured-type octocoral sinularia numerosa |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346896/ https://www.ncbi.nlm.nih.gov/pubmed/25654226 http://dx.doi.org/10.3390/ijms16023298 |
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