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Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients

Background: Diabetes mellitus is known to exacerbate bacterial infection, but its effect on the severity of viral infection has not been well studied. The severity of thrombocytopenia is an indicator of the severity of dengue virus infection. We investigated whether diabetes is associated with throm...

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Autores principales: Chen, Chung-Yuan, Lee, Mei-Yueh, Lin, Kun-Der, Hsu, Wei-Hao, Lee, Yaun-Jinn, Hsiao, Pi-Jung, Shin, Shyi-Jang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346928/
https://www.ncbi.nlm.nih.gov/pubmed/25674854
http://dx.doi.org/10.3390/ijms16023820
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author Chen, Chung-Yuan
Lee, Mei-Yueh
Lin, Kun-Der
Hsu, Wei-Hao
Lee, Yaun-Jinn
Hsiao, Pi-Jung
Shin, Shyi-Jang
author_facet Chen, Chung-Yuan
Lee, Mei-Yueh
Lin, Kun-Der
Hsu, Wei-Hao
Lee, Yaun-Jinn
Hsiao, Pi-Jung
Shin, Shyi-Jang
author_sort Chen, Chung-Yuan
collection PubMed
description Background: Diabetes mellitus is known to exacerbate bacterial infection, but its effect on the severity of viral infection has not been well studied. The severity of thrombocytopenia is an indicator of the severity of dengue virus infection. We investigated whether diabetes is associated with thrombocytopenia in dengue-infected patients. Methods: We studied clinical characteristics of 644 patients with dengue infection at a university hospital during the epidemic on 1 June 2002 to 31 December 2002 in Taiwan. Platelet counts and biochemical data were compared between patients with and without diabetes. Potential risk factors associated with thrombocytopenia were explored using regression analyses. Results: Dengue-infected patients with diabetes had lower platelet counts than patients without diabetes during the first three days (54.54 ± 51.69 vs. 86.58 ± 63.4 (p ≤ 0.001), 43.98 ± 44.09 vs. 64.52 ± 45.06 (p = 0.002), 43.86 ± 35.75 vs. 62.72 ± 51.2 (p = 0.012)). Diabetes mellitus, death, dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF) and increased glutamic-pyruvate transaminase (GPT) levels were significantly associated with lower platelet counts during the first day of hospitalization for dengue fever with regression β of −13.981 (95% confidence interval (CI) −27.587, −0.374), −26.847 (95% CI −37.562, −16.132), and 0.054 (95% CI 0.015, 0.094) respectively. Older age, hypoalbuminemia, and hypertriglyceridemia were independently correlated with thrombocytopenia in dengue patients with or without diabetes with regression β of −2.947 (p = 0.004), 2.801 (p = 0.005), and −3.568 (p ≤ 0.001), respectively. Diabetic patients with dengue had a higher rate of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) than non-diabetic patients. They also had lower blood albumin, were older, and higher triglyceride levels. Older age, hypoalbuminemia, and hypertriglyceridemia were independently correlated with thrombocytopenia in dengue patients. Conclusions: Dengue patients with diabetes tended to have more severe thrombocytopenia and were more likely to have DHF/DSS. Older age, hypoalbuminemia, and hypertriglyceridemia were independently associated with more severe thrombocytopenia in dengue patients.
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spelling pubmed-43469282015-04-03 Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients Chen, Chung-Yuan Lee, Mei-Yueh Lin, Kun-Der Hsu, Wei-Hao Lee, Yaun-Jinn Hsiao, Pi-Jung Shin, Shyi-Jang Int J Mol Sci Article Background: Diabetes mellitus is known to exacerbate bacterial infection, but its effect on the severity of viral infection has not been well studied. The severity of thrombocytopenia is an indicator of the severity of dengue virus infection. We investigated whether diabetes is associated with thrombocytopenia in dengue-infected patients. Methods: We studied clinical characteristics of 644 patients with dengue infection at a university hospital during the epidemic on 1 June 2002 to 31 December 2002 in Taiwan. Platelet counts and biochemical data were compared between patients with and without diabetes. Potential risk factors associated with thrombocytopenia were explored using regression analyses. Results: Dengue-infected patients with diabetes had lower platelet counts than patients without diabetes during the first three days (54.54 ± 51.69 vs. 86.58 ± 63.4 (p ≤ 0.001), 43.98 ± 44.09 vs. 64.52 ± 45.06 (p = 0.002), 43.86 ± 35.75 vs. 62.72 ± 51.2 (p = 0.012)). Diabetes mellitus, death, dengue shock syndrome (DSS) and dengue hemorrhagic fever (DHF) and increased glutamic-pyruvate transaminase (GPT) levels were significantly associated with lower platelet counts during the first day of hospitalization for dengue fever with regression β of −13.981 (95% confidence interval (CI) −27.587, −0.374), −26.847 (95% CI −37.562, −16.132), and 0.054 (95% CI 0.015, 0.094) respectively. Older age, hypoalbuminemia, and hypertriglyceridemia were independently correlated with thrombocytopenia in dengue patients with or without diabetes with regression β of −2.947 (p = 0.004), 2.801 (p = 0.005), and −3.568 (p ≤ 0.001), respectively. Diabetic patients with dengue had a higher rate of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS) than non-diabetic patients. They also had lower blood albumin, were older, and higher triglyceride levels. Older age, hypoalbuminemia, and hypertriglyceridemia were independently correlated with thrombocytopenia in dengue patients. Conclusions: Dengue patients with diabetes tended to have more severe thrombocytopenia and were more likely to have DHF/DSS. Older age, hypoalbuminemia, and hypertriglyceridemia were independently associated with more severe thrombocytopenia in dengue patients. MDPI 2015-02-10 /pmc/articles/PMC4346928/ /pubmed/25674854 http://dx.doi.org/10.3390/ijms16023820 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chen, Chung-Yuan
Lee, Mei-Yueh
Lin, Kun-Der
Hsu, Wei-Hao
Lee, Yaun-Jinn
Hsiao, Pi-Jung
Shin, Shyi-Jang
Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title_full Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title_fullStr Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title_full_unstemmed Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title_short Diabetes Mellitus Increases Severity of Thrombocytopenia in Dengue-Infected Patients
title_sort diabetes mellitus increases severity of thrombocytopenia in dengue-infected patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346928/
https://www.ncbi.nlm.nih.gov/pubmed/25674854
http://dx.doi.org/10.3390/ijms16023820
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