Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl)phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compou...

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Autores principales: Chang, Chi-Fen, Hsu, Yu-Lin, Lee, Chao-Ying, Wu, Chia-Hua, Wu, Yang-Chang, Chuang, Ta-Hsien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346938/
https://www.ncbi.nlm.nih.gov/pubmed/25686035
http://dx.doi.org/10.3390/ijms16023980
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author Chang, Chi-Fen
Hsu, Yu-Lin
Lee, Chao-Ying
Wu, Chia-Hua
Wu, Yang-Chang
Chuang, Ta-Hsien
author_facet Chang, Chi-Fen
Hsu, Yu-Lin
Lee, Chao-Ying
Wu, Chia-Hua
Wu, Yang-Chang
Chuang, Ta-Hsien
author_sort Chang, Chi-Fen
collection PubMed
description Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl)phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines.
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spelling pubmed-43469382015-04-03 Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis Chang, Chi-Fen Hsu, Yu-Lin Lee, Chao-Ying Wu, Chia-Hua Wu, Yang-Chang Chuang, Ta-Hsien Int J Mol Sci Article Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl)phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines. MDPI 2015-02-12 /pmc/articles/PMC4346938/ /pubmed/25686035 http://dx.doi.org/10.3390/ijms16023980 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Chi-Fen
Hsu, Yu-Lin
Lee, Chao-Ying
Wu, Chia-Hua
Wu, Yang-Chang
Chuang, Ta-Hsien
Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title_full Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title_fullStr Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title_full_unstemmed Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title_short Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis
title_sort isolation and cytotoxicity evaluation of the chemical constituents from cephalantheropsis gracilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346938/
https://www.ncbi.nlm.nih.gov/pubmed/25686035
http://dx.doi.org/10.3390/ijms16023980
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