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Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine
Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications re...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346943/ https://www.ncbi.nlm.nih.gov/pubmed/25689424 http://dx.doi.org/10.3390/ijms16024043 |
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author | Skalova, Stepanka Svadlakova, Tereza Qureshi, Wasay Mohiuddin Shaikh Dev, Kapil Mokry, Jaroslav |
author_facet | Skalova, Stepanka Svadlakova, Tereza Qureshi, Wasay Mohiuddin Shaikh Dev, Kapil Mokry, Jaroslav |
author_sort | Skalova, Stepanka |
collection | PubMed |
description | Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications related to the usage of pluripotent embryonic stem cells (ESCs) in human medicine, particularly ESC isolation and histoincompatibility were bypassed with induced pluripotent stem cell (iPSC) technology. The human iPSCs can be used for studying embryogenesis, disease modeling, drug testing and regenerative medicine. iPSCs can be diverted to different cell lineages using small molecules and growth factors. In this review we have focused on iPSC differentiation towards cardiac and neuronal lineages. Moreover, we deal with the use of iPSCs in regenerative medicine and modeling diseases like myocardial infarction, Timothy syndrome, dilated cardiomyopathy, Parkinson’s, Alzheimer’s and Huntington’s disease. Despite the promising potential of iPSCs, genome contamination and low efficacy of cell reprogramming remain significant challenges. |
format | Online Article Text |
id | pubmed-4346943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-43469432015-04-03 Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine Skalova, Stepanka Svadlakova, Tereza Qureshi, Wasay Mohiuddin Shaikh Dev, Kapil Mokry, Jaroslav Int J Mol Sci Review Stem cells are unique pools of cells that are crucial for embryonic development and maintenance of adult tissue homeostasis. The landmark Nobel Prize winning research by Yamanaka and colleagues to induce pluripotency in somatic cells has reshaped the field of stem cell research. The complications related to the usage of pluripotent embryonic stem cells (ESCs) in human medicine, particularly ESC isolation and histoincompatibility were bypassed with induced pluripotent stem cell (iPSC) technology. The human iPSCs can be used for studying embryogenesis, disease modeling, drug testing and regenerative medicine. iPSCs can be diverted to different cell lineages using small molecules and growth factors. In this review we have focused on iPSC differentiation towards cardiac and neuronal lineages. Moreover, we deal with the use of iPSCs in regenerative medicine and modeling diseases like myocardial infarction, Timothy syndrome, dilated cardiomyopathy, Parkinson’s, Alzheimer’s and Huntington’s disease. Despite the promising potential of iPSCs, genome contamination and low efficacy of cell reprogramming remain significant challenges. MDPI 2015-02-13 /pmc/articles/PMC4346943/ /pubmed/25689424 http://dx.doi.org/10.3390/ijms16024043 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Skalova, Stepanka Svadlakova, Tereza Qureshi, Wasay Mohiuddin Shaikh Dev, Kapil Mokry, Jaroslav Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title | Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title_full | Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title_fullStr | Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title_full_unstemmed | Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title_short | Induced Pluripotent Stem Cells and Their Use in Cardiac and Neural Regenerative Medicine |
title_sort | induced pluripotent stem cells and their use in cardiac and neural regenerative medicine |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346943/ https://www.ncbi.nlm.nih.gov/pubmed/25689424 http://dx.doi.org/10.3390/ijms16024043 |
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